ID   SOMA_ORENI              Reviewed;         204 AA.
AC   P13391;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2670496; DOI=10.1089/dna.1.1989.8.271;
RA   Rentier-Delrue F., Swennen D., Philippart J.C., L'Hoir C., Lion M.,
RA   Benrubi O., Martial J.A.;
RT   "Tilapia growth hormone: molecular cloning of cDNA and expression in
RT   Escherichia coli.";
RL   DNA 8:271-278(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1572545; DOI=10.1016/0378-1119(92)90402-b;
RA   Ber R., Daniel V.;
RT   "Structure and sequence of the growth hormone-encoding gene from Tilapia
RT   nilotica.";
RL   Gene 113:245-250(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8462869; DOI=10.1016/0378-1119(93)90321-s;
RA   Ber R., Daniel V.;
RT   "Sequence analysis suggests a recent duplication of the growth hormone-
RT   encoding gene in Tilapia nilotica.";
RL   Gene 125:143-150(1993).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       involved in the regulation of several anabolic processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M26916; AAA49437.1; -; mRNA.
DR   EMBL; M84774; AAA49626.1; -; Genomic_DNA.
DR   PIR; JN0484; JN0484.
DR   AlphaFoldDB; P13391; -.
DR   SMR; P13391; -.
DR   STRING; 8128.ENSONIP00000011557; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   HOGENOM; CLU_088274_2_1_1; -.
DR   InParanoid; P13391; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IMP:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..204
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033043"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..177
FT                   /evidence="ECO:0000250"
FT   DISULFID        194..202
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  23110 MW;  C0CD77E004B810C8 CRC64;
     MNSVVLLLSV VCLGVSSQQI TDSQRLFSIA VNRVTHLHLL AQRLFSDFES SLQTEEQRQL
     NKIFLQDFCN SDYIISPIDK HETQRSSVLK LLSISYGLVE SWEFPSRSLS GGSSLRNQIS
     PRLSELKTGI LLLIRANQDE AENYPDTDTL QHAPYGNYYQ SLGGNESLRQ TYELLACFKK
     DMHKVETYLT VAKCRLSPEA NCTL