ID   SOMA_PANGG              Reviewed;         200 AA.
AC   P69162; P29970;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Pangasianodon gigas (Mekong giant catfish) (Pangasius gigas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Pangasiidae; Pangasianodon.
OX   NCBI_TaxID=30993;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7959001; DOI=10.1016/0378-1119(94)90160-0;
RA   Lemaire C., Warit S., Panyim S.;
RT   "Giant catfish Pangasianodon gigas growth hormone-encoding cDNA: cloning
RT   and sequencing by one-sided polymerase chain reaction.";
RL   Gene 149:271-276(1994).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; L27835; AAA62615.1; -; mRNA.
DR   PIR; I51114; I51114.
DR   AlphaFoldDB; P69162; -.
DR   SMR; P69162; -.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042538; P:hyperosmotic salinity response; ISS:UniProtKB.
DR   GO; GO:1903576; P:response to L-arginine; ISS:UniProtKB.
DR   GO; GO:0043434; P:response to peptide hormone; ISS:UniProtKB.
DR   GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..200
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033045"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         182
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..173
FT                   /evidence="ECO:0000250"
FT   DISULFID        190..198
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   200 AA;  22562 MW;  10918AAAFE256459 CRC64;
     MARVLVVLSV VVASLFFSQG ATFENQRLFN NAVIRVQHLH QLAAKMMDDF EEALLPEERK
     QLSKIFPLSF CNSDSIEAPA GKDETQKSSV LKLLHTSYRL IESWEFPSKN LGNPNHISEK
     LADLKMGIGV LIEGCLDGQT SLDENDSLAP PFEDFYQTLS EGNLRKSFRL LSCFKKDMHK
     VETYLSVAKC RRSLDSNCTL