ID   SOMA_PAROL              Reviewed;         190 AA.
AC   P09537;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2567501; DOI=10.1093/nar/17.10.3977;
RA   Mori H., Kimura T., Tsunenari T., Ogura T., Niki H., Ezaki B.,
RA   Shigesada K., Hiraga S.;
RT   "The complete cDNA sequence for the premature form of growth hormone of the
RT   flounder Paralichthys olivaceus.";
RL   Nucleic Acids Res. 17:3977-3977(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2909523; DOI=10.1016/s0021-9258(17)31259-0;
RA   Watahiki M., Yamamoto M., Yamakawa M., Tanaka M., Nakashima K.;
RT   "Conserved and unique amino acid residues in the domains of the growth
RT   hormones. Flounder growth hormone deduced from the cDNA sequence has the
RT   minimal size in the growth hormone prolactin gene family.";
RL   J. Biol. Chem. 264:312-316(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8522198; DOI=10.1016/0378-1119(95)00532-b;
RA   Tanaka M., Toma Y., Ohkubo T., Sudo S., Nakashima K.;
RT   "Sequence of the flounder (Paralichthys olivaceus) growth hormone-encoding
RT   gene and its promoter region.";
RL   Gene 165:321-322(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-190.
RC   TISSUE=Pituitary;
RX   PubMed=3194207; DOI=10.1093/nar/16.21.10362;
RA   Momota H., Kosugi R., Ohgai H., Hara A., Ishioka H.;
RT   "Amino acid sequence of flounder growth hormone deduced from a cDNA
RT   sequence.";
RL   Nucleic Acids Res. 16:10362-10362(1988).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X12887; CAA31378.1; -; mRNA.
DR   EMBL; M23439; AAA49443.1; -; mRNA.
DR   EMBL; D29737; BAA06159.1; -; Genomic_DNA.
DR   EMBL; X15055; CAA33155.1; -; mRNA.
DR   PIR; S04355; S04355.
DR   RefSeq; XP_019963990.1; XM_020108431.1.
DR   AlphaFoldDB; P09537; -.
DR   SMR; P09537; -.
DR   GeneID; 109643344; -.
DR   KEGG; pov:109643344; -.
DR   CTD; 2688; -.
DR   OrthoDB; 1190548at2759; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 2.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..190
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033047"
FT   DISULFID        69..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21453 MW;  D04D9F3BCE3DE5A1 CRC64;
     MNRVILLLSV MCVGVSSQPI TENQRLFSIA VGRVQYLHLV AKKLFSDFEN SLQLEDQRLL
     NKIASKEFCH SDNFLSPIDK HETQGSSVQK LLSVSYRLIE SWEFFSRFLV ASFAVRTQVT
     SKLSELKMGL LKLIEANQDG AGGFSESSVL QLTPYGNSEL FACFKKDMHK VETYLTVAKC
     RLFPEANCTL