ID   SOMA_PROAN              Reviewed;         206 AA.
AC   O73848;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Protopterus annectens (African lungfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Protopteridae;
OC   Protopterus.
OX   NCBI_TaxID=7888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9882551; DOI=10.1006/gcen.1998.7185;
RA   May D., Alrubaian J., Patel S., Dores R.M., Rand-Weaver M.;
RT   "Studies on the GH/SL gene family: cloning of African lungfish (Protopterus
RT   annectens) growth hormone and somatolactin and toad (Bufo marinus) growth
RT   hormone.";
RL   Gen. Comp. Endocrinol. 113:121-135(1999).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF062745; AAC16496.1; -; mRNA.
DR   AlphaFoldDB; O73848; -.
DR   SMR; O73848; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..206
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033049"
FT   DISULFID        75..179
FT                   /evidence="ECO:0000250"
FT   DISULFID        196..204
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   206 AA;  23408 MW;  9ED9D1E3BC307B57 CRC64;
     MAGLHFFPAL LALLMASLQT HQGFPMPSLS SLLSNAVQRA NYLHNLAGDR YRDFEQNYIS
     DEQRHSIKNS PAAYCYSESS PAPTGKEDAR QKSDMDLLRF SLSLIQAWIS PLQILGRPFG
     SPDAYDKLLD LEKGLQVLMR ELEDGSSRGL SLLKHTYDKF SANQFSEEAT LKNYSLLACF
     KKDMHKVETY LRVMKCRRFP ESNCTI