ID   SOMA_RHIMB              Reviewed;         213 AA.
AC   O73849;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH;
OS   Rhinella marina (Cane toad) (Bufo marinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Rhinella.
OX   NCBI_TaxID=8386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9882551; DOI=10.1006/gcen.1998.7185;
RA   May D., Alrubaian J., Patel S., Dores R.M., Rand-Weaver M.;
RT   "Studies on the GH/SL gene family: cloning of African lungfish (Protopterus
RT   annectens) growth hormone and somatolactin and toad (Bufo marinus) growth
RT   hormone.";
RL   Gen. Comp. Endocrinol. 113:121-135(1999).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF062746; AAC16497.1; -; mRNA.
DR   AlphaFoldDB; O73849; -.
DR   SMR; O73849; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..213
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033007"
FT   DISULFID        77..186
FT                   /evidence="ECO:0000250"
FT   DISULFID        203..211
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  24556 MW;  CB24A0F31BB0DEFF CRC64;
     MASGLCSSLG LLLIMCLQSP PGFSAFPQIP LASLLNNAVI RAQYIRQVVA DTYRDYEQTF
     IREDKRYSNK NSYAMFCYSE TIPAPTDKDN THQKSDIDLL RFSLTLIQSW MTPVQSLNKL
     FTNQVFGNAV YEKLRDLEEG LYALMRELDD GNARNYGLLT FTYDKFDPHP DSDDDGRIKN
     YGLLSCFKKD MHKVETYLKV MKCRRFVESN CMV