SOMA_SAIBB
ID SOMA_SAIBB Reviewed; 217 AA.
AC P58343;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11371582; DOI=10.1093/oxfordjournals.molbev.a003895;
RA Liu J.-C., Makova K.D., Adkins R.M., Gibson S., Li W.-H.;
RT "Episodic evolution of growth hormone in primates and emergence of the
RT species specificity of human growth hormone receptor.";
RL Mol. Biol. Evol. 18:945-953(2001).
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF339060; AAK62287.1; -; mRNA.
DR RefSeq; NP_001266907.1; NM_001279978.1.
DR AlphaFoldDB; P58343; -.
DR SMR; P58343; -.
DR STRING; 39432.ENSSBOP00000016551; -.
DR GeneID; 101039453; -.
DR CTD; 2688; -.
DR OrthoDB; 1190548at2759; -.
DR Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW Secreted; Signal; Zinc.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..217
FT /note="Somatotropin"
FT /id="PRO_0000032999"
FT BINDING 44
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 200
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01241"
FT DISULFID 79..191
FT /evidence="ECO:0000250"
FT DISULFID 208..215
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24864 MW; 9515289992C529F7 CRC64;
MATGSRTSLL LAFTLLCLPQ LKEAGAFPTI PLSRLLDNAM LRAHRLHQLA FDTYQEFEEA
YIPKEQKYSF LQNPQTSLCF SESIPTPASK KETQQKSNLE LLRISLILIQ SWFEPVQLLR
SVFANSLLYG VSDSDVYEYL KDLEEGIQTL MERLEDGSPR TGAIFRQTYS KFDINSQNDD
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF