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SOMA_SAIBB
ID   SOMA_SAIBB              Reviewed;         217 AA.
AC   P58343;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11371582; DOI=10.1093/oxfordjournals.molbev.a003895;
RA   Liu J.-C., Makova K.D., Adkins R.M., Gibson S., Li W.-H.;
RT   "Episodic evolution of growth hormone in primates and emergence of the
RT   species specificity of human growth hormone receptor.";
RL   Mol. Biol. Evol. 18:945-953(2001).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF339060; AAK62287.1; -; mRNA.
DR   RefSeq; NP_001266907.1; NM_001279978.1.
DR   AlphaFoldDB; P58343; -.
DR   SMR; P58343; -.
DR   STRING; 39432.ENSSBOP00000016551; -.
DR   GeneID; 101039453; -.
DR   CTD; 2688; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..217
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032999"
FT   BINDING         44
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        79..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24864 MW;  9515289992C529F7 CRC64;
     MATGSRTSLL LAFTLLCLPQ LKEAGAFPTI PLSRLLDNAM LRAHRLHQLA FDTYQEFEEA
     YIPKEQKYSF LQNPQTSLCF SESIPTPASK KETQQKSNLE LLRISLILIQ SWFEPVQLLR
     SVFANSLLYG VSDSDVYEYL KDLEEGIQTL MERLEDGSPR TGAIFRQTYS KFDINSQNDD
     ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF
 
 
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