SOMA_SHEEP
ID SOMA_SHEEP Reviewed; 217 AA.
AC P67930; P01247; P07289; Q29404;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3453044; DOI=10.1071/bi9870459;
RA Byrne C.R., Wilson B.W., Ward K.A.;
RT "The isolation and characterisation of the ovine growth hormone gene.";
RL Aust. J. Biol. Sci. 40:459-468(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3174441; DOI=10.1093/nar/16.18.9046;
RA Orian J.M., O'Mahoney J.V., Brandon M.R.;
RT "Cloning and sequencing of the ovine growth hormone gene.";
RL Nucleic Acids Res. 16:9046-9046(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2660907; DOI=10.1016/0167-4781(80)90016-0;
RA Warwick J.M., Wallis O.C., Wallis M.;
RT "Cloning, sequence and expression in Escherichia coli of cDNA for ovine
RT pregrowth hormone.";
RL Biochim. Biophys. Acta 1008:247-250(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=1459643;
RA Guron C., Rao K.B., Jain S.K., Totey S.M., Talwar G.P.;
RT "Cloning and nucleotide sequencing of sheep growth hormone cDNA.";
RL Indian J. Exp. Biol. 30:659-663(1992).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Awassi;
RX PubMed=9321473; DOI=10.1007/s003359900563;
RA Ofir R., Gootwine E.;
RT "Ovine growth hormone gene duplication -- structural and evolutionary
RT implications.";
RL Mamm. Genome 8:770-772(1997).
RN [6]
RP PROTEIN SEQUENCE OF 28-217.
RX PubMed=4736985; DOI=10.1016/0003-9861(73)90299-3;
RA Li C.H., Gordon D., Knorr J.;
RT "The primary structure of sheep pituitary growth hormone.";
RL Arch. Biochem. Biophys. 156:493-508(1973).
RN [7]
RP PROTEIN SEQUENCE OF 150-217.
RX PubMed=5062423; DOI=10.1016/s0006-291x(72)80091-3;
RA Bellair J.T.;
RT "Ovine growth hormone. Sequence of the C-terminal 68 amino acids.";
RL Biochem. Biophys. Res. Commun. 46:1128-1134(1972).
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; M37310; AAA31527.1; -; Genomic_DNA.
DR EMBL; X12546; CAA31063.1; -; Genomic_DNA.
DR EMBL; X15976; CAA34098.1; -; mRNA.
DR EMBL; S50877; AAB24467.2; -; mRNA.
DR EMBL; AF002113; AAB63273.1; -; Genomic_DNA.
DR EMBL; AF002111; AAB63273.1; JOINED; Genomic_DNA.
DR EMBL; AF002112; AAB63273.1; JOINED; Genomic_DNA.
DR PIR; S02225; STSH.
DR RefSeq; NP_001009315.2; NM_001009315.3.
DR AlphaFoldDB; P67930; -.
DR BMRB; P67930; -.
DR SMR; P67930; -.
DR STRING; 9940.ENSOARP00000014952; -.
DR MetOSite; P67930; -.
DR Ensembl; ENSOART00000015172; ENSOARP00000014952; ENSOARG00000013932.
DR Ensembl; ENSOART00020025658; ENSOARP00020021272; ENSOARG00020016511.
DR GeneID; 443329; -.
DR KEGG; oas:443329; -.
DR CTD; 14599; -.
DR eggNOG; ENOG502R5GJ; Eukaryota.
DR HOGENOM; CLU_088274_2_1_1; -.
DR OMA; QTAFCFS; -.
DR OrthoDB; 1190548at2759; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000013932; Expressed in pituitary gland and 36 other tissues.
DR ExpressionAtlas; P67930; baseline.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0055074; P:calcium ion homeostasis; IMP:AgBase.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0042538; P:hyperosmotic salinity response; IMP:AgBase.
DR GO; GO:0030073; P:insulin secretion; ISS:AgBase.
DR GO; GO:0010960; P:magnesium ion homeostasis; IMP:AgBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:1903408; P:positive regulation of P-type sodium:potassium-exchanging transporter activity; IMP:AgBase.
DR GO; GO:0032930; P:positive regulation of superoxide anion generation; IMP:AgBase.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR GO; GO:0055078; P:sodium ion homeostasis; IMP:AgBase.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW Phosphoprotein; Reference proteome; Secreted; Signal; Zinc.
FT SIGNAL 1..27
FT /evidence="ECO:0000269|PubMed:4736985"
FT CHAIN 28..217
FT /note="Somatotropin"
FT /id="PRO_0000033000"
FT BINDING 46
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 199
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01241"
FT DISULFID 79..190
FT DISULFID 207..215
FT CONFLICT 89
FT /note="G -> S (in Ref. 1; AAA31527)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="N -> D (in Ref. 6; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="R -> L (in Ref. 1; AAA31527)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="T -> R (in Ref. 4; AAB24467)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24631 MW; 77EC37A102584429 CRC64;
MMAAGPRTSL LLAFTLLCLP WTQVVGAFPA MSLSGLFANA VLRAQHLHQL AADTFKEFER
TYIPEGQRYS IQNTQVAFCF SETIPAPTGK NEAQQKSDLE LLRISLLLIQ SWLGPLQFLS
RVFTNSLVFG TSDRVYEKLK DLEEGILALM RELEDVTPRA GQILKQTYDK FDTNMRSDDA
LLKNYGLLSC FRKDLHKTET YLRVMKCRRF GEASCAF
