ID   SOMA_SIGGU              Reviewed;         196 AA.
AC   Q9IBE5;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Siganus guttatus (Orange-spotted spinefoot) (Chaetodon guttatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Siganidae; Siganus.
OX   NCBI_TaxID=92439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=10642447; DOI=10.1006/gcen.1999.7409;
RA   Ayson F.G., de Jesus E.G., Amemiya Y., Moriyama S., Hirano T., Kawauchi H.;
RT   "Isolation, cDNA cloning, and growth promoting activity of rabbitfish
RT   (Siganus guttatus) growth hormone.";
RL   Gen. Comp. Endocrinol. 117:251-259(2000).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AB031298; BAA92144.1; -; mRNA.
DR   AlphaFoldDB; Q9IBE5; -.
DR   SMR; Q9IBE5; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..196
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033055"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        186..194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  22325 MW;  08721FD11C0F3F20 CRC64;
     MEKVVLLLSV LSLGVVCPQP MTDSQRFSIA VSRIHYLHQV AQRSFFTFES SLSAEDQRQL
     NKIFLQDSCN SDYIRSPIDK HETQRSSVMK LLSISYRLVE SWEYPSRALI GGSTNQISNK
     LSELKLGIRL LMEANQDGAE IFPESSAFQL DYQSLGTDDP RQMYELLACF KKDMHKVETY
     LTVAKCRLSP EANCTL