ID   SOMA_SOLSE              Reviewed;         203 AA.
AC   P45643;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Solea senegalensis (Senegalese sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Soleidae; Solea.
OX   NCBI_TaxID=28829;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8056337; DOI=10.1016/0378-1119(94)90012-4;
RA   Pendon C., Martinez-Barbera J.-P., Perez-Sanchez J., Rodriguez R.B.,
RA   Grenett H., Valdivia M.M.;
RT   "Cloning of the sole (Solea senegalensis) growth hormone-encoding cDNA.";
RL   Gene 145:237-240(1994).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U01143; AAA60372.1; -; mRNA.
DR   PIR; I51363; I51363.
DR   AlphaFoldDB; P45643; -.
DR   SMR; P45643; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..203
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033056"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         185
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..176
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..201
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   203 AA;  23238 MW;  99A015F9549BC271 CRC64;
     MDRVVIVLSV LSVAASSQSI LDQRRFSIAV SRVQHIHLLA QKYFSDFESS LQTEDQRQVN
     KIFLQDFCNS DDIISPIDKH DTQRSSVLKL LSISVRLIES WEFSSRFVTW STFPRNQISH
     KLSELKTGIR MLIEANQDGA EVFSDSSTFQ LAPYGNFYQS LGGDESLRRN YELLACFKKD
     MHKVETYLTV AKCRLSPEAN CTL