ID   SOMA_SPAAU              Reviewed;         204 AA.
AC   P29971; Q90Y60; Q91440;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 3.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=1889749; DOI=10.1016/0378-1119(91)90280-o;
RA   Funkenstein B., Chen T.T., Powers D.A., Cavari B.;
RT   "Cloning and sequencing of the gilthead seabream (Sparus aurata) growth
RT   hormone-encoding cDNA.";
RL   Gene 103:243-247(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Martinez-Barbera J.-P.;
RL   Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Rodriguez R.B., Sanchez-Ayuso M., Parrilla R.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11081974; DOI=10.1139/g00-051;
RA   Almuly R., Cavari B., Ferstman H., Kolodny O., Funkenstein B.;
RT   "Genomic structure and sequence of the gilthead seabream (Sparus aurata)
RT   growth hormone-encoding gene: identification of minisatellite polymorphism
RT   in intron I.";
RL   Genome 43:836-845(2000).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S54890; AAB19750.2; -; mRNA.
DR   EMBL; U01301; AAA03329.1; -; mRNA.
DR   EMBL; U48221; AAA90968.1; -; Genomic_DNA.
DR   EMBL; AF195646; AAG28461.1; -; Genomic_DNA.
DR   PIR; JH0577; JH0577.
DR   AlphaFoldDB; P29971; -.
DR   SMR; P29971; -.
DR   Ensembl; ENSSAUT00010041396; ENSSAUP00010039266; ENSSAUG00010016543.
DR   GeneTree; ENSGT00950000182818; -.
DR   OMA; NSQVAFC; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..204
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033057"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..177
FT                   /evidence="ECO:0000250"
FT   DISULFID        194..202
FT                   /evidence="ECO:0000250"
FT   CONFLICT        56
FT                   /note="E -> D (in Ref. 2; AAA03329)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="R -> P (in Ref. 1; AAB19750)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        71
FT                   /note="S -> C (in Ref. 1; AAB19750)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        147
FT                   /note="S -> R (in Ref. 1; AAB19750)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  23105 MW;  0641B1FE04ED87C9 CRC64;
     MDRVVLMLSV MSLGVSSQPI TDGQRLFSIA VSRVQHLHLL AQRLFSDFES SLQTEEQRQL
     NKIFLQDFCN SDYIISPIDK HETQRSSVLK LLSISYRLVE SWEFPSRSLS GGSAPRNQIS
     PKLSELKTGI HLLIRANEDG AEIFPDSSAL QLAPYGNYYQ SLGTDESLRR TYELLACFKK
     DMHKVETYLT VAKCRLSPEA NCTL