ID   SOMA_TAKRU              Reviewed;         196 AA.
AC   O12980;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9099882; DOI=10.1016/s0378-1119(96)00750-0;
RA   Venkatesh B., Brenner S.;
RT   "Genomic structure and sequence of the pufferfish (Fugu rubripes) growth
RT   hormone-encoding gene: a comparative analysis of teleost growth hormone
RT   genes.";
RL   Gene 187:211-215(1997).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U63807; AAC60105.1; -; Genomic_DNA.
DR   AlphaFoldDB; O12980; -.
DR   SMR; O12980; -.
DR   STRING; 31033.ENSTRUP00000004705; -.
DR   Ensembl; ENSTRUT00000052286; ENSTRUP00000048994; ENSTRUG00000002048.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   InParanoid; O12980; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 2.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   CHAIN           17..196
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033023"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         17
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        186..194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  22081 MW;  1842EFAC6C169AAF CRC64;
     MDKVILVLLM SLGASSQPLT DTPRLFSMAV SRVQHLHLLA QRLFADFESS LQTDEQRQLN
     KKFLPFCNSD SIISPNDKHE TQRSSVLKLL SISYRLIESW DFPSLSLSGG LSPKLSDLKT
     GILLLIKASQ DGADMFSEST TLQLGPYENY YQNLGGEEPL KRTYELLTCF KKDMHKVETY
     LTVAKCRLSP EANCTL