ID   SOMA_THUAL              Reviewed;         187 AA.
AC   P34747;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=gh;
OS   Thunnus albacares (Yellowfin tuna) (Neothunnus macropterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8236;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Pituitary;
RA   Kariya Y., Sato N., Kawazoe I., Kimura S., Miyazaki N., Nonaka M.,
RA   Kawauchi H.;
RT   "Isolation and characterization of growth hormone from a marine fish, tuna
RT   (Thunnus albacares).";
RL   Agric. Biol. Chem. 53:1679-1687(1989).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; JU0030; JU0030.
DR   AlphaFoldDB; P34747; -.
DR   SMR; P34747; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Pyrrolidone carboxylic acid; Secreted; Zinc.
FT   CHAIN           1..187
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181338"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         169
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        52..160
FT                   /evidence="ECO:0000250"
FT   DISULFID        177..185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  21305 MW;  FD9AF11A318C8F5E CRC64;
     QPITDSQRLF SIAVSRIQHL HLLAQRLFSD FESSLQTEEQ RQLNKIFLQD FCNSDYIISP
     IDKHETQRSS VLKLLSISYR LVQSWEFPSR SLSGGSALRN QISPKLSELK TGIHLLIRAN
     QDGAEMFADS SALQLAPYGN YYQSLGADES LRRSYELLAC FKKDMHKVET YLTVAKCRLS
     PEANCTL