ID   SOMA_TRIVU              Reviewed;         215 AA.
AC   O62754;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Trichosurus vulpecula (Brush-tailed possum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Phalangeridae; Trichosurus.
OX   NCBI_TaxID=9337;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9653023; DOI=10.1006/gcen.1998.7090;
RA   Saunders M.C., Deakin J., Harrison G.A., Curlewis J.D.;
RT   "cDNA cloning of growth hormone from the brushtail possum (Trichosurus
RT   vulpecula).";
RL   Gen. Comp. Endocrinol. 111:68-75(1998).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF052192; AAC08986.1; -; mRNA.
DR   AlphaFoldDB; O62754; -.
DR   SMR; O62754; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Secreted; Signal;
KW   Zinc.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..215
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033002"
FT   BINDING         44
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         197
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        77..188
FT                   /evidence="ECO:0000250"
FT   DISULFID        205..213
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   215 AA;  24353 MW;  F241085B4A7352D1 CRC64;
     MAPGARISLL LLITFTLLGP QRSGAFPAMP LSSLFANAVL RAQHLHQLVA DTYKEFERTY
     IPEAQRHSIQ STQTAFCFSE TIPAPTGKDE AQQRSDVELL RFSLLLIQSW LSPVQFLSRV
     FTNSLVFGTS DRVYEKLRDL EEGIQALMQE LEDGSSRGGL VLKTTYDKFD TNLRSDEALL
     KNYGLLSCFK KDLHKAETYL RVMKCRRFVE SSCAF