ID   SOMA_VERVA              Reviewed;         203 AA.
AC   O93566;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Verasper variegatus (Spotted flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae; Verasper.
OX   NCBI_TaxID=82366;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lee J.H., Lee S.J., Kim Y., Jeon I.G., Kim K.K., Kim K.W.;
RT   "Molecular cloning of the spotted flounder (Verasper variegatus) growth
RT   hormone cDNA by polymerase chain reaction.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF086787; AAC36716.1; -; mRNA.
DR   AlphaFoldDB; O93566; -.
DR   SMR; O93566; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..203
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033060"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..176
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..201
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   203 AA;  23143 MW;  0BA26CB4AFCA294E CRC64;
     MNRVILLLSV MCVGVSSQPI TENQRLFSIA VGRVQYLHLV AKKLFSEFEN SQLEDQHPLN
     KIFLQDFCHS DYFLSPIDKH ETQRSSVLKL LSISYRLIEC WEFSSRFLVA GFAERAQVTS
     KLSELKTGLM KLIEANQDGA GGFSESSVIQ LTPYGNYYQS VGVDESFRLN YELFACFKKD
     MHKVETYLTV AKCRLSPEAN CTL