ID   SOMA_VICPA              Reviewed;         190 AA.
AC   P37885;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=GH1;
OS   Vicugna pacos (Alpaca) (Lama pacos).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna.
OX   NCBI_TaxID=30538;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1761365; DOI=10.1111/j.1399-3011.1991.tb01428.x;
RA   de Jimenez Bonino M.B., de Nue I.A., Ore R., Sanchez D., Ferrara P.,
RA   Capdevielle J., Cascone O.;
RT   "Primary structure of alpaca growth hormone.";
RL   Int. J. Pept. Protein Res. 38:193-197(1991).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; A61584; A61584.
DR   AlphaFoldDB; P37885; -.
DR   SMR; P37885; -.
DR   Proteomes; UP000504605; Genome assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Phosphoprotein; Reference proteome; Secreted; Zinc.
FT   CHAIN           1..190
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181329"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        52..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21789 MW;  A7C67266A8B96A10 CRC64;
     FPAMPLSSLF ANAVLRAQHL HQLAADTYKE FERTYIPEGQ RYSIQNAQAA FCFSETIPAP
     TGKDEAQQRS DVELLRFSLL LIQSWLGPVQ FLSRVFTNSL VFGTSDRVYE KLKDLEEGIQ
     ALMRELEDGS PRAGQILRQT YDKFDTNLRS DDALLKNYGL LSCFKKDLHK AETYLRVMKC
     RRFVESSCAF