ID   SOML1_SPAAU             Reviewed;         231 AA.
AC   P54863;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Somatolactin-1;
DE            Short=SL;
DE   Flags: Precursor;
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8954766; DOI=10.1006/gcen.1996.0178;
RA   Astola A., Pendon C., Ortiz M., Valdivia M.M.;
RT   "Cloning and expression of somatolactin, a pituitary hormone related to
RT   growth hormone and prolactin from gilthead seabream, Sparus aurata.";
RL   Gen. Comp. Endocrinol. 104:330-336(1996).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; L49205; AAA98734.1; -; mRNA.
DR   AlphaFoldDB; P54863; -.
DR   SMR; P54863; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..231
FT                   /note="Somatolactin-1"
FT                   /id="PRO_0000033077"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..205
FT                   /evidence="ECO:0000250"
FT   DISULFID        222..230
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   231 AA;  26962 MW;  67A44E7D43E02504 CRC64;
     MRMIRAIKQG QWAVLLWPYL LTASIPLDCR DEQGVLSHCP SISQEKLLDR VIQHAELIYR
     VSEESCSLFE EMFIPFPLQL QRNQAGYPCI TKALPIPSSK SEIQQISDKW LLHSVLMLVQ
     SWIEPLVYLQ TTLNRYDGVP DMLLNKTKWV SEKLMSLEQG VVVLIKKMLD EEMMTTTYSE
     QGLFQDDGQP EMLEYVMRDY TLLSCFKKDA HKMEILLKLL KCRQNDMHSC R