ID   SOML_ANGAN              Reviewed;         228 AA.
AC   Q90216;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9099860; DOI=10.1016/s0378-1119(96)00777-9;
RA   May D., Todd C.M., Rand-Weaver M.;
RT   "cDNA cloning of eel (Anguilla anguilla) somatolactin.";
RL   Gene 188:63-67(1997).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U63884; AAB53035.1; -; mRNA.
DR   AlphaFoldDB; Q90216; -.
DR   SMR; Q90216; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..228
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033065"
FT   CARBOHYD        141
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..200
FT                   /evidence="ECO:0000250"
FT   DISULFID        217..225
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   228 AA;  26184 MW;  B06183BC2A95E098 CRC64;
     MFSIRMNKVL QGFVCLMLTH RIVGYPMDCK EDQDGTRCPS ISLDKLLDRI IQHAELIYRV
     SEESCTLFEE MYIPSSIRAQ LSRGGNACST RSVPIQGRIQ QISDKWLLHS TLVVIQSWTG
     PLQSLQITMD LYDNAPDGLL NKTKWMSTKL MNLEQGVTVL IRKMLNEDIL VSDPSQNLTH
     FATQPNMVES VLTDYTLLTC FRKDAHRVET FLKLLKCRQS DRLSCFLY