SOML_CYCLU
ID SOML_CYCLU Reviewed; 229 AA.
AC P45640;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Somatolactin;
DE Short=SL;
DE Flags: Precursor;
OS Cyclopterus lumpus (Lumpsucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Cottales; Cyclopteridae; Cyclopterus.
OX NCBI_TaxID=8103;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7689905;
RA Iraqi F., Gong Z., Hew C.-L., Crim L.W.;
RT "Isolation and characterization of somatolactin genes from two cold water
RT marine teleosts, lumpfish (Cyclopterus lumpus) and halibut (Hippoglossus
RT hippoglossus).";
RL Mol. Mar. Biol. Biotechnol. 2:96-103(1993).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L02118; AAC38004.1; -; mRNA.
DR AlphaFoldDB; P45640; -.
DR SMR; P45640; -.
DR Ensembl; ENSCLMT00005028332; ENSCLMP00005027155; ENSCLMG00005013242.
DR GeneTree; ENSGT00950000182818; -.
DR Proteomes; UP000694565; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034976; Somatolactin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..229
FT /note="Somatolactin"
FT /id="PRO_0000033067"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..39
FT /evidence="ECO:0000250"
FT DISULFID 87..203
FT /evidence="ECO:0000250"
FT DISULFID 220..228
FT /evidence="ECO:0000250"
SQ SEQUENCE 229 AA; 26413 MW; B8B9CA30C1731101 CRC64;
MHLVSVIQRG VWAVLLWPNL LASSVPLDCR EEQGILSRCP SISQEKLLDR VIEHAELIYR
VSEESCSLYE DMFIPLQFQR NQVGYACITK TLPVPSSKNE IQQISDKWLL HSVLMLVQSW
IEPLVYLQTS LDRYNAAPEM LLNKTKWVSE KLISLEQGVV VLIKKMLDEG MLTINHSEQG
LLQNGVQPQM LESVMRDYTL LSCFKKDAHK MEAFLKLLKC RQTDRYNCS