ID   SOML_GADMO              Reviewed;         235 AA.
AC   P21919;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Gadus morhua (Atlantic cod).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1936917; DOI=10.1016/0016-6480(91)90141-r;
RA   Takayama Y., Ono M., Rand-Weaver M., Kawauchi H.;
RT   "Greater conservation of somatolactin, a presumed pituitary hormone of the
RT   growth hormone/prolactin family, than of growth hormone in teleost fish.";
RL   Gen. Comp. Endocrinol. 83:366-374(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 27-235.
RC   TISSUE=Pituitary;
RX   PubMed=1993170; DOI=10.1021/bi00220a010;
RA   Rand-Weaver M., Noso T., Muramoto K., Kawauchi H.;
RT   "Isolation and characterization of somatolactin, a new protein related to
RT   growth hormone and prolactin from Atlantic cod (Gadus morhua) pituitary
RT   glands.";
RL   Biochemistry 30:1509-1515(1991).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- PTM: A smaller variant of SL is probably not glycosylated.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D10639; BAA01486.1; -; mRNA.
DR   PIR; A49762; A49762.
DR   AlphaFoldDB; P21919; -.
DR   SMR; P21919; -.
DR   STRING; 8049.ENSGMOP00000014235; -.
DR   Ensembl; ENSGMOT00000014600; ENSGMOP00000014235; ENSGMOG00000013307.
DR   GeneTree; ENSGT00950000182818; -.
DR   Proteomes; UP000694546; Chromosome 16.
DR   Bgee; ENSGMOG00000013307; Expressed in sexually immature organism and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:1993170"
FT   CHAIN           27..235
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033068"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        31..41
FT   DISULFID        91..207
FT   DISULFID        224..232
SQ   SEQUENCE   235 AA;  26994 MW;  42DAD0230D15B12F CRC64;
     MHTLAAVVVL QVCWAAVLWP CPPTHSSPVD CREEQAGSSQ CPTISQEKLL DRVIQHTELI
     YRVSEESCSM FEDMFVPFPV RLQRNQAGNT CITKDFPIPT SKNELQQISD TWLLHSVLML
     VQSWIEPLVY LQTTLDRYDD VPDVLLNKTK WMSEKLISLE QGVVVLIRKM LDGAILNSSY
     NEYSAVQLDV QPEVLESILR DYNVLCCFKK DAHKIETILK LLKCRQIDKY NCALY