ID   SOML_HIPHI              Reviewed;         230 AA.
AC   P45641;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Hippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Hippoglossus.
OX   NCBI_TaxID=8267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7689905;
RA   Iraqi F., Gong Z., Hew C.-L., Crim L.W.;
RT   "Isolation and characterization of somatolactin genes from two cold water
RT   marine teleosts, lumpfish (Cyclopterus lumpus) and halibut (Hippoglossus
RT   hippoglossus).";
RL   Mol. Mar. Biol. Biotechnol. 2:96-103(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; L02117; AAC38003.1; -; mRNA.
DR   AlphaFoldDB; P45641; -.
DR   SMR; P45641; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..230
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033069"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  26519 MW;  1E3C16622F75946A CRC64;
     MNMMTVKQGV WAALLWPYLL AASIPLDCKD EQGSFSACPS ISQEKLLDRV IQHAELIYRV
     SEESCSMFEE MFVPFPLRLQ RNQAGYACIT KALPIPSSKS EIQQISDTWL LHSVLLLVQS
     WIDPLVYLQT TLDRYDNASE MLLNKTKWVS DKLISLEQGV VVLIRKMLDE GMLTATYNEQ
     GLFQYDVLPD MLESVMRDYT LLSCFKKDAH KMEIFLKLLK CRQTDKYNCP