ID   SOML_ICTPU              Reviewed;         230 AA.
AC   Q9I8J9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Tang Y.;
RT   "A study on the channel catfish (Ictalurus punctatus) growth hormone gene
RT   family: structures of growth hormone and prolactin genes and somatolactin
RT   cDNA, their evolutionary implications and expression in the pituitary
RT   gland.";
RL   Thesis (1993), University of Maryland, United States.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF267991; AAF78945.1; -; mRNA.
DR   RefSeq; NP_001187017.1; NM_001200088.1.
DR   AlphaFoldDB; Q9I8J9; -.
DR   SMR; Q9I8J9; -.
DR   STRING; 7998.ENSIPUP00000030302; -.
DR   GeneID; 100304502; -.
DR   KEGG; ipu:100304502; -.
DR   CTD; 32601; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..230
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033070"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..202
FT                   /evidence="ECO:0000250"
FT   DISULFID        219..227
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  26113 MW;  E98122F5742D54F3 CRC64;
     MIKTKVLQAW MGIWLCAVNG LLGSDQDCSD RDPTGSRCSI SVEKLLDRAI QHAELIYRIS
     DEARTLFEEM FIPLLIPAHQ VHGGNSCTSN LVRVPISKLE IQQISDKWLL HSISILVQVW
     IEPLADLQDS LDMYDNVPSS LISKTRWMST KLMNLKQGVL VLMSKMLDEG SVELENNESM
     LRHIVAPAMA EHVLRDYAVL SCFKKDAHKM ETFLKLLRCR QTDNPTCSLF