ID   SOML_ONCKE              Reviewed;         233 AA.
AC   P24405;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1922096; DOI=10.1210/mend-5-6-778;
RA   Takayama Y., Rand-Weaver M., Kawauchi H., Ono M.;
RT   "Gene structure of chum salmon somatolactin, a presumed pituitary hormone
RT   of the growth hormone/prolactin family.";
RL   Mol. Endocrinol. 5:778-786(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1936917; DOI=10.1016/0016-6480(91)90141-r;
RA   Takayama Y., Ono M., Rand-Weaver M., Kawauchi H.;
RT   "Greater conservation of somatolactin, a presumed pituitary hormone of the
RT   growth hormone/prolactin family, than of growth hormone in teleost fish.";
RL   Gen. Comp. Endocrinol. 83:366-374(1991).
CC   -!- FUNCTION: May be associated with ion regulation and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; D10640; BAA01487.1; -; mRNA.
DR   EMBL; D10638; BAA01485.1; -; Genomic_DNA.
DR   PIR; A23729; A23729.
DR   AlphaFoldDB; P24405; -.
DR   SMR; P24405; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..233
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033071"
FT   DISULFID        29..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..205
FT                   /evidence="ECO:0000250"
FT   DISULFID        222..230
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   233 AA;  26883 MW;  178F385705F0A461 CRC64;
     MNMMQVMQSV VWAVLLWPCL VSLGVPLECK DEQGSIILCA SISKEKLLDR VIQHAELIYR
     VSEESCTLFE EMFVPFPMRS QRNQAGYTCA TKAFPIPGSK SEIQQISDKW LLHSVLILVQ
     SWIEPLVYLQ TTLDRYDDAP DTLLKKTKWV SEKLLSLEQG VVVLIRKMLD DDMLTTSYYE
     QGVAPYALQP EVLESVLRDY TLLSCFKKDA HKMETFLKLL KCRQTDKYSC FLH