ID   SOML_ORYLA              Reviewed;         230 AA.
AC   Q6E211;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=HNI;
RX   PubMed=15249680; DOI=10.1073/pnas.0401278101;
RA   Fukamachi S., Sugimoto M., Mitani H., Shima A.;
RT   "Somatolactin selectively regulates proliferation and morphogenesis of
RT   neural-crest derived pigment cells in medaka.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:10661-10666(2004).
CC   -!- FUNCTION: Selectively regulates proliferation and morphogenesis of
CC       neural-crest derived pigment cells. {ECO:0000269|PubMed:15249680}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AY605289; AAT58046.1; -; Genomic_DNA.
DR   EMBL; AY530202; AAS98173.1; -; mRNA.
DR   RefSeq; NP_001098260.1; NM_001104790.1.
DR   AlphaFoldDB; Q6E211; -.
DR   SMR; Q6E211; -.
DR   STRING; 8090.ENSORLP00000016883; -.
DR   Ensembl; ENSORLT00020016330; ENSORLP00020009836; ENSORLG00020010734.
DR   GeneID; 100049402; -.
DR   KEGG; ola:100049402; -.
DR   CTD; 572522; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 13.
DR   Proteomes; UP000265200; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0070186; F:growth hormone activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..230
FT                   /note="Somatolactin"
FT                   /id="PRO_0000042586"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  26656 MW;  5243C495547E22CB CRC64;
     MHTKVLQQGL WALLLWPHLF TVSVPLDCRD DQASLARCPS ISQEKLLDRV IHHAELIYRV
     SEESCSLFEE MFIPLPLRLQ SNQGGYACIT KALPIPSSKS EIQQLSDKWL LHSVLMLVQS
     WIEPLVYLQM TLDRYDHAPD MLLNKTKWVS EKLISLEQGV VVLIKKMLDE GAMTTTYSEQ
     GAFQYDVQLE MLEYVMRDYT LLTCLKKDAH KMETFLKLLK CRQTDKYNCA