ID   SOML_PAROL              Reviewed;         231 AA.
AC   P20362;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 25-47.
RC   TISSUE=Pituitary;
RX   PubMed=2349240; DOI=10.1073/pnas.87.11.4330;
RA   Ono M., Takayama Y., Rand-Weaver M., Sakata S., Yasunaga T., Noso T.,
RA   Kawauchi H.;
RT   "cDNA cloning of somatolactin, a pituitary protein related to growth
RT   hormone and prolactin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:4330-4334(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M33696; AAA49445.1; -; mRNA.
DR   EMBL; M33695; AAA49444.1; -; mRNA.
DR   PIR; A35793; A35793.
DR   RefSeq; XP_019950511.1; XM_020094952.1.
DR   AlphaFoldDB; P20362; -.
DR   SMR; P20362; -.
DR   GeneID; 109634465; -.
DR   KEGG; pov:109634465; -.
DR   CTD; 572522; -.
DR   OrthoDB; 1190548at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:2349240"
FT   CHAIN           25..231
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033072"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..205
FT                   /evidence="ECO:0000250"
FT   DISULFID        222..230
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   231 AA;  26731 MW;  8C7EDAA6BB912BAB CRC64;
     MNMMTVKQQG VWAALLWPYL LTASIPLDCK EEQGSLSRCP SISQEKLLDR VIQHAELIYR
     VSEESCSMFE EMFVPFPLRL QRNQAGYACI TKALPIPSSK SEIQQISDTW LLHSVLMLVQ
     SWIEPLVYLQ TTLDRYDNAP DMLLNKTKWV SDKLISLEQG VVVLIRKMLD EGMLTATYNE
     QGLFQYDAQP DMLESVMRDY TLLSCFKKDA HKMEIFLKLL KCRQTDKYNC A