ID   SOML_PROAN              Reviewed;         232 AA.
AC   O73847;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Protopterus annectens (African lungfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Protopteridae;
OC   Protopterus.
OX   NCBI_TaxID=7888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9882551; DOI=10.1006/gcen.1998.7185;
RA   May D., Alrubaian J., Patel S., Dores R.M., Rand-Weaver M.;
RT   "Studies on the GH/SL gene family: cloning of African lungfish (Protopterus
RT   annectens) growth hormone and somatolactin and toad (Bufo marinus) growth
RT   hormone.";
RL   Gen. Comp. Endocrinol. 113:121-135(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Amemiya Y., Takahashi A., Kawauchi H.;
RT   "African lungfish somatolactin cDNA.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF062744; AAC16495.1; -; mRNA.
DR   EMBL; AB017766; BAA33422.1; -; mRNA.
DR   AlphaFoldDB; O73847; -.
DR   SMR; O73847; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..232
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033073"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        31..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        91..206
FT                   /evidence="ECO:0000250"
FT   DISULFID        223..231
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   232 AA;  26883 MW;  54B58651DB4F23E1 CRC64;
     MHNWKGVWLC SLFLTFGQLW NGILLAYPLD CKDEQGSYTR CTSISLEKLL DRAIQHAELL
     YRVSEESCTI FEDNFAPFSL VSQRSRNFNS CYTKGLRLPS SKSEAQQVSD KWLLHSVLVL
     VQSWIEPFVY LQRTLDTYNS LPGSLVNKTK WVSDKLPSLE QGIVVLIRKM LHEGLITTDF
     QQSVIEIEPS PEITDSSARD YMILNCFRKD AHKMETFLKL LKCRQIKKLN CY