ID   SOML_SOLSE              Reviewed;         230 AA.
AC   P45642;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Solea senegalensis (Senegalese sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Soleidae; Solea.
OX   NCBI_TaxID=28829;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7926805; DOI=10.1016/0378-1119(94)90071-x;
RA   Pendon C., Martinez-Barbera J.-P., Valdivia M.M.;
RT   "Cloning of a somatolactin-encoding cDNA from sole (Solea senegalensis).";
RL   Gene 147:227-230(1994).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U06753; AAA61873.1; -; mRNA.
DR   PIR; JC2582; JC2582.
DR   AlphaFoldDB; P45642; -.
DR   SMR; P45642; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..230
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033076"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        221..229
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  26586 MW;  ACDB39117EE3D49A CRC64;
     MMTAVKQSGV WAVLLWPYLL AVSIQLDCRD EQGNMSRCPF ISQEKLLDRI IQHAELISRI
     SEESCSLFEE LFVPFPLRLQ RNTVGYACIT KALPIPSSKS EIQQISDKWL LQSVLTLVQS
     WIEPLVYLQT TLDRYDNAPD VLLNKTKWVS EKLVSLEQGV VVLIRKMLDE GTLTTTYNEQ
     DLLQYDVLPD MLESVMRDYT LLSCFKKDAH KMEIFLKLLK CRQTDKFNCA