ID   SOML_TETMU              Reviewed;         229 AA.
AC   Q9I9H4;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Somatolactin;
DE            Short=SL;
DE   Flags: Precursor;
OS   Tetraodon miurus (Congo puffer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=94908;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Rand-Weaver M., May D.;
RT   "Cloning and sequencing of Tetraodon miurus somatolactin.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF253066; AAF64522.1; -; mRNA.
DR   AlphaFoldDB; Q9I9H4; -.
DR   SMR; Q9I9H4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034976; Somatolactin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF3; PTHR11417:SF3; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..229
FT                   /note="Somatolactin"
FT                   /id="PRO_0000033079"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        26..36
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..203
FT                   /evidence="ECO:0000250"
FT   DISULFID        220..228
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  26126 MW;  C10CCF295D28C447 CRC64;
     MAALQEVLLA VLLWPVLVTI SNPINCGDEQ SSLSNCLSIS EEKLLDRESF STLSSSIVFL
     KNHVLCLRRC LSHSQYSSRQ ARQENACMTK VLPIPSSKSE IQQITDKWLL HAVLMLVQSW
     IKPLVYLQTT MVRYDYASDV LLNKTKWVLE KLISLEQGVV ILIKKILNEA VMTTTVSELD
     LFPTDLQPDI LESVMNDYSL LSCFKKDARK IEILLKLLKC RRNDMYNCA