ID   SON1_ARATH              Reviewed;         370 AA.
AC   Q8LL17;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Protein SUPPRESSOR OF NIM1 1;
GN   Name=SON1; OrderedLocusNames=At2g17310; ORFNames=F5J6.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   MUTAGENESIS OF ARG-257.
RX   PubMed=12119368; DOI=10.1105/tpc.001867;
RA   Kim H.S., Delaney T.P.;
RT   "Arabidopsis SON1 is an F-box protein that regulates a novel induced
RT   defense response independent of both salicylic acid and systemic acquired
RT   resistance.";
RL   Plant Cell 14:1469-1482(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
CC   -!- FUNCTION: Regulates negatively a plant defense signaling pathway which
CC       is independent of salicylic acid (SA) and systemic acquired resistance
CC       (SAR). Confers sensitivity to P.syringae and P.parasitica.
CC       {ECO:0000269|PubMed:12119368}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous, at low levels.
CC       {ECO:0000269|PubMed:12119368}.
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DR   EMBL; AF472589; AAM89220.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06612.1; -; Genomic_DNA.
DR   EMBL; BX821299; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; F84550; F84550.
DR   RefSeq; NP_179323.1; NM_127286.2.
DR   AlphaFoldDB; Q8LL17; -.
DR   STRING; 3702.AT2G17310.1; -.
DR   PaxDb; Q8LL17; -.
DR   PRIDE; Q8LL17; -.
DR   EnsemblPlants; AT2G17310.1; AT2G17310.1; AT2G17310.
DR   GeneID; 816238; -.
DR   Gramene; AT2G17310.1; AT2G17310.1; AT2G17310.
DR   KEGG; ath:AT2G17310; -.
DR   Araport; AT2G17310; -.
DR   TAIR; locus:2827561; AT2G17310.
DR   HOGENOM; CLU_034692_2_1_1; -.
DR   InParanoid; Q8LL17; -.
DR   OMA; TRNIGIW; -.
DR   OrthoDB; 965469at2759; -.
DR   PhylomeDB; Q8LL17; -.
DR   PRO; PR:Q8LL17; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8LL17; baseline and differential.
DR   Genevisible; Q8LL17; AT.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:TAIR.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:TAIR.
DR   GO; GO:0009617; P:response to bacterium; IMP:TAIR.
DR   GO; GO:0009620; P:response to fungus; IMP:TAIR.
DR   InterPro; IPR006527; F-box-assoc_dom_typ1.
DR   InterPro; IPR017451; F-box-assoc_interact_dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF07734; FBA_1; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   TIGRFAMs; TIGR01640; F_box_assoc_1; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Plant defense; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Protein SUPPRESSOR OF NIM1 1"
FT                   /id="PRO_0000285581"
FT   DOMAIN          1..43
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   MUTAGEN         257
FT                   /note="R->Q: In son1-1; confers resistance to pathogens
FT                   such as P.syringae and P.parasitica."
FT                   /evidence="ECO:0000269|PubMed:12119368"
FT   CONFLICT        327
FT                   /note="E -> D (in Ref. 4; BX821299)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   370 AA;  43322 MW;  3AD24687C0D96309 CRC64;
     MALPWELEED ILSRLPPISL VRFRTVSKHW NSLFNDKTFI NNHLSRSRPE FIILTNSKIY
     SVDIIDHNNI DPTIRLHEIP TYDIHSRGTD LNRTIINTCD EFLFYNYRYW DNMTALWNPW
     LRQVRWIEYA NQEFCVFGLG YDNSRPEKVY KILGHLFCHG KVLRDQKVVI YECASDSLRF
     IDRPEDDDWP ITETAKRSNV SLNGNLYWFG CSNYENDEYY IRIFDFSTED FKPFCLLPCQ
     MSHSTDELVL AVYKGDRFSL LKQCSVTREI GVWVTKERIS NDNGNGGEGV EWLKLMTLSK
     PNLPKLFGTV SYFIYGKTLY MCNGDDETAL ACIYIVREDV CKKFQIGSGN INCRHCVYTP
     NLLSLPLFIG