ID   SOP4_KLULA              Reviewed;         234 AA.
AC   Q6CW19;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Protein SOP4;
DE   Flags: Precursor;
GN   Name=SOP4; OrderedLocusNames=KLLA0B07645g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the export of PMA1, possibly through the
CC       monitoring or assisting of PMA1 folding and acquisition of competence
CC       to enter vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOP4 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02263.1; -; Genomic_DNA.
DR   RefSeq; XP_451870.1; XM_451870.1.
DR   AlphaFoldDB; Q6CW19; -.
DR   SMR; Q6CW19; -.
DR   STRING; 28985.XP_451870.1; -.
DR   PRIDE; Q6CW19; -.
DR   EnsemblFungi; CAH02263; CAH02263; KLLA0_B07645g.
DR   GeneID; 2897048; -.
DR   KEGG; kla:KLLA0_B07645g; -.
DR   eggNOG; ENOG502RXGD; Eukaryota.
DR   HOGENOM; CLU_102669_0_0_1; -.
DR   InParanoid; Q6CW19; -.
DR   OMA; PYITVEL; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031395; Sop4.
DR   Pfam; PF17081; SOP4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Protein transport;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..234
FT                   /note="Protein SOP4"
FT                   /id="PRO_0000324497"
FT   TOPO_DOM        20..191
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   234 AA;  27120 MW;  DC4B7D951E15F95A CRC64;
     MNFVLFCFLV WQFVNPGAAF DIKGRLDLKV RNVSRHDISR TYFNLYRIRN PNDDSEWDSY
     SQSSKLENIN GEFTFSDVPI DTGINRTTYF TLHSHSNEFN LKPNRILIQI VGNGQDQEPN
     LSAFENRFGR EYFPSPDITY PETLNPLPLD SANRLTITTM NKQPYRKYIK IRNPGILESG
     PIASVLRSKF KLAGVVTVIF LVLFPILLEK FDPETAKAMR QEKMHRENAK YVSK