ID   SOPE_SALEE              Reviewed;         240 AA.
AC   Q8VSR1; Q8VLN0;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Guanine nucleotide exchange factor SopE;
DE   AltName: Full=Effector protein SopE;
DE   AltName: Full=Toxin SopE;
GN   Name=sopE;
OS   Salmonella enterica VII.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=59208;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROPHAGE-RELATED REGION.
RC   STRAIN=SARC15 / s3013, and SARC16 / s3014;
RX   PubMed=11545581; DOI=10.1006/jmbi.2001.4950;
RA   Mirold S., Rabsch W., Tschaepe H., Hardt W.-D.;
RT   "Transfer of the Salmonella type III effector sopE between unrelated phage
RT   families.";
RL   J. Mol. Biol. 312:7-16(2001).
CC   -!- FUNCTION: Activator for both CDC42 and RAC1 by directly engaging these
CC       Rho GTPases and acting as potent guanine nucleotide exchange factor
CC       (GEF). This activation results in actin cytoskeleton rearrangements and
CC       stimulates membrane ruffling, promoting bacterial entry into non-
CC       phagocytic cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the
CC       type III secretion system 1 (SPI-1 TTSS). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Encoded within a prophage region, which is only present
CC       in very few Salmonella isolates.
CC   -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC       {ECO:0000305}.
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DR   EMBL; AF378113; AAL67193.1; -; Genomic_DNA.
DR   EMBL; AF378114; AAL67194.1; -; Genomic_DNA.
DR   EMBL; AY034829; AAK63084.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VSR1; -.
DR   SMR; Q8VSR1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IEA:InterPro.
DR   Gene3D; 1.10.4120.10; -; 1.
DR   InterPro; IPR005414; SopE.
DR   InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR   InterPro; IPR016019; SopE_GEF_dom.
DR   InterPro; IPR016018; SopE_N_dom.
DR   Pfam; PF05364; SecIII_SopE_N; 1.
DR   Pfam; PF07487; SopE_GEF; 1.
DR   PIRSF; PIRSF034781; SecIII_sopE; 1.
DR   PRINTS; PR01593; SOPEPROTEIN.
DR   SUPFAM; SSF81832; SSF81832; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW   Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..240
FT                   /note="Guanine nucleotide exchange factor SopE"
FT                   /id="PRO_0000220733"
FT   REGION          78..240
FT                   /note="GEF catalytic domain"
FT                   /evidence="ECO:0000250"
FT   VARIANT         63
FT                   /note="A -> T (in strain: SARC16 / s3014)"
FT   VARIANT         73
FT                   /note="A -> E (in strain: SARC16 / s3014)"
FT   VARIANT         76
FT                   /note="A -> T (in strain: SARC16 / s3014)"
SQ   SEQUENCE   240 AA;  26526 MW;  AF54AC5A79BFDF52 CRC64;
     MTKITLSLQN FRIQKQETTP LKEKSTEKTS LAKAILAVKN HFNKLSSNLS ERFISHKNTE
     SSATHSHRGS ASADRAVLTN KVVKEFMLQT LNDMDIRGNA SKDPAYASQT REAILSAVYS
     KNKDQCCKLL ISKGINIAPF LKEIGEAAQN AGLPGATKND VFTPSGAGAN PFITPLVSSA
     NCKYPHMFIN QHQQASFKIY AEKIIMTEVA PLFNECVMPT PQQFHLILEN IANKYIQNTP