ID   SOPE_SALET              Reviewed;         240 AA.
AC   Q7BD17;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Guanine nucleotide exchange factor SopE;
DE   AltName: Full=Effector protein SopE;
DE   AltName: Full=Toxin SopE;
GN   Name=sopE;
OS   Salmonella enterica I.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=59201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROPHAGE-RELATED REGION.
RC   STRAIN=SARC2 / s3333;
RX   PubMed=11545581; DOI=10.1006/jmbi.2001.4950;
RA   Mirold S., Rabsch W., Tschaepe H., Hardt W.-D.;
RT   "Transfer of the Salmonella type III effector sopE between unrelated phage
RT   families.";
RL   J. Mol. Biol. 312:7-16(2001).
CC   -!- FUNCTION: Activator for both CDC42 and RAC1 by directly engaging these
CC       Rho GTPases and acting as potent guanine nucleotide exchange factor
CC       (GEF). This activation results in actin cytoskeleton rearrangements and
CC       stimulates membrane ruffling, promoting bacterial entry into non-
CC       phagocytic cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the
CC       type III secretion system 1 (SPI-1 TTSS). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Encoded within a lambda-like prophage region with
CC       similarity to GIFSY phages.
CC   -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC       {ECO:0000305}.
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DR   EMBL; AF378115; AAL67195.1; -; Genomic_DNA.
DR   RefSeq; WP_000161708.1; NZ_JABUVK010000007.1.
DR   AlphaFoldDB; Q7BD17; -.
DR   SMR; Q7BD17; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IEA:InterPro.
DR   Gene3D; 1.10.4120.10; -; 1.
DR   InterPro; IPR005414; SopE.
DR   InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR   InterPro; IPR016019; SopE_GEF_dom.
DR   InterPro; IPR016018; SopE_N_dom.
DR   Pfam; PF05364; SecIII_SopE_N; 1.
DR   Pfam; PF07487; SopE_GEF; 1.
DR   PIRSF; PIRSF034781; SecIII_sopE; 1.
DR   PRINTS; PR01593; SOPEPROTEIN.
DR   SUPFAM; SSF81832; SSF81832; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW   Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..240
FT                   /note="Guanine nucleotide exchange factor SopE"
FT                   /id="PRO_0000220734"
FT   REGION          78..240
FT                   /note="GEF catalytic domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   240 AA;  26685 MW;  F636E9D437018D03 CRC64;
     MTKITLSPQN FRIQKQETTL LKEKSTEKNS LAKSILAVKN HFIELRSKLS ERFISHKNTE
     SSATHFHRGS ASEGRAVLTN KVVKDFMLQT LNDIDIRGSA SKDPAYASQT REAILSAVYS
     KNKDQCCNLL ISKGINIAPF LQEIGEAAKN AGLPGTTKND VFTPSGAGAN PFITPLISSA
     NSKYPRMFIN QHQQASFKIY AEKIIMTEVA PLFNECAMPT PQQFQLILEN IANKYIQYTP