ID   SOPE_SALHO              Reviewed;         240 AA.
AC   Q8VSR2; Q8VSR3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Guanine nucleotide exchange factor SopE;
DE   AltName: Full=Effector protein SopE;
DE   AltName: Full=Toxin SopE;
GN   Name=sopE;
OS   Salmonella houtenae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=59205;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SARC10 / s3027, and SARC9 / s3015;
RX   PubMed=11545581; DOI=10.1006/jmbi.2001.4950;
RA   Mirold S., Rabsch W., Tschaepe H., Hardt W.-D.;
RT   "Transfer of the Salmonella type III effector sopE between unrelated phage
RT   families.";
RL   J. Mol. Biol. 312:7-16(2001).
CC   -!- FUNCTION: Activator for both CDC42 and RAC1 by directly engaging these
CC       Rho GTPases and acting as potent guanine nucleotide exchange factor
CC       (GEF). This activation results in actin cytoskeleton rearrangements and
CC       stimulates membrane ruffling, promoting bacterial entry into non-
CC       phagocytic cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the
CC       type III secretion system 1 (SPI-1 TTSS). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Encoded within a lambda-like prophage region with
CC       similarity to GIFSY phages.
CC   -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC       {ECO:0000305}.
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DR   EMBL; AF378111; AAL67191.1; -; Genomic_DNA.
DR   EMBL; AF378112; AAL67192.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VSR2; -.
DR   SMR; Q8VSR2; -.
DR   STRING; 523831.SEHO0A_01824; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IEA:InterPro.
DR   Gene3D; 1.10.4120.10; -; 1.
DR   InterPro; IPR005414; SopE.
DR   InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR   InterPro; IPR016019; SopE_GEF_dom.
DR   InterPro; IPR016018; SopE_N_dom.
DR   Pfam; PF05364; SecIII_SopE_N; 1.
DR   Pfam; PF07487; SopE_GEF; 1.
DR   PIRSF; PIRSF034781; SecIII_sopE; 1.
DR   PRINTS; PR01593; SOPEPROTEIN.
DR   SUPFAM; SSF81832; SSF81832; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW   Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..240
FT                   /note="Guanine nucleotide exchange factor SopE"
FT                   /id="PRO_0000220737"
FT   REGION          78..240
FT                   /note="GEF catalytic domain"
FT                   /evidence="ECO:0000250"
FT   VARIANT         55
FT                   /note="S -> L (in strain: SARC9 / s3015)"
FT   VARIANT         97
FT                   /note="I -> R (in strain: SARC9 / s3015)"
FT   VARIANT         182
FT                   /note="S -> C (in strain: SARC9 / s3015)"
SQ   SEQUENCE   240 AA;  26537 MW;  2A7A4A9B5CEC9974 CRC64;
     MTKITLSLQN FRIQKQEITP LKEKSTEKTS LAKAILAVKN HFNKLSSNLS ERFISHKNTE
     SSATHSHRGS ASEDRAVLTN KVVKEFMLQT LNDMDIIGNA SKDPAYASQT REAILSAVYS
     KNKDQCCKLL ISKGINIAPF LKEIGEAAQN AGLPGATKND VFTPSGAGAN PFITPLVSSA
     NSKYPHMFIN QHQQASFKIY AEKIIMTEVA PLFNECVMPT PQQFHLILEN IANKYIQNTP