ID   SOPE_SALTI              Reviewed;         240 AA.
AC   Q9RPM6; Q7ALR5; Q7C5D1;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Guanine nucleotide exchange factor SopE;
DE   AltName: Full=Effector protein SopE;
DE   AltName: Full=Toxin SopE;
GN   Name=sopE; OrderedLocusNames=STY4609, t4303;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROPHAGE-RELATED REGION.
RC   STRAIN=x3744;
RX   PubMed=10449782; DOI=10.1073/pnas.96.17.9845;
RA   Mirold S., Rabsch W., Rohde M., Stender S., Tschaepe H., Ruessmann H.,
RA   Igwe E., Hardt W.-D.;
RT   "Isolation of a temperate bacteriophage encoding the type III effector
RT   protein SopE from an epidemic Salmonella typhimurium strain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:9845-9850(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Activator for both CDC42 and RAC1 by directly engaging these
CC       Rho GTPases and acting as potent guanine nucleotide exchange factor
CC       (GEF). This activation results in actin cytoskeleton rearrangements and
CC       stimulates membrane ruffling, promoting bacterial entry into non-
CC       phagocytic cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Secreted via the type III
CC       secretion system 1 (SPI-1 TTSS).
CC   -!- MISCELLANEOUS: Encoded within a prophage region, which is only present
CC       in very few Salmonella isolates.
CC   -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC       {ECO:0000305}.
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DR   EMBL; AF153829; AAD54239.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06731.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71759.1; -; Genomic_DNA.
DR   PIR; AF1035; AF1035.
DR   RefSeq; NP_458691.1; NC_003198.1.
DR   RefSeq; WP_000161708.1; NZ_WSUR01000075.1.
DR   AlphaFoldDB; Q9RPM6; -.
DR   SMR; Q9RPM6; -.
DR   STRING; 220341.16505382; -.
DR   EnsemblBacteria; AAO71759; AAO71759; t4303.
DR   KEGG; stt:t4303; -.
DR   KEGG; sty:STY4609; -.
DR   PATRIC; fig|220341.7.peg.4707; -.
DR   eggNOG; ENOG5033HJR; Bacteria.
DR   HOGENOM; CLU_107159_0_0_6; -.
DR   OMA; YATIYSE; -.
DR   PHI-base; PHI:6799; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IEA:InterPro.
DR   Gene3D; 1.10.4120.10; -; 1.
DR   InterPro; IPR005414; SopE.
DR   InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR   InterPro; IPR016019; SopE_GEF_dom.
DR   InterPro; IPR016018; SopE_N_dom.
DR   Pfam; PF05364; SecIII_SopE_N; 1.
DR   Pfam; PF07487; SopE_GEF; 1.
DR   PIRSF; PIRSF034781; SecIII_sopE; 1.
DR   PRINTS; PR01593; SOPEPROTEIN.
DR   SUPFAM; SSF81832; SSF81832; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW   Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..240
FT                   /note="Guanine nucleotide exchange factor SopE"
FT                   /id="PRO_0000220739"
FT   REGION          78..240
FT                   /note="GEF catalytic domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   240 AA;  26685 MW;  F636E9D437018D03 CRC64;
     MTKITLSPQN FRIQKQETTL LKEKSTEKNS LAKSILAVKN HFIELRSKLS ERFISHKNTE
     SSATHFHRGS ASEGRAVLTN KVVKDFMLQT LNDIDIRGSA SKDPAYASQT REAILSAVYS
     KNKDQCCNLL ISKGINIAPF LQEIGEAAKN AGLPGTTKND VFTPSGAGAN PFITPLISSA
     NSKYPRMFIN QHQQASFKIY AEKIIMTEVA PLFNECAMPT PQQFQLILEN IANKYIQYTP