ID   SOR3_CAEEL              Reviewed;         531 AA.
AC   Q11193;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Sop-2-related protein 3;
GN   Name=sor-3; ORFNames=C04E7.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION AS SOR-3, FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=17215367; DOI=10.1073/pnas.0610261104;
RA   Yang Y., Sun Y., Luo X., Zhang Y., Chen Y., Tian E., Lints R., Zhang H.;
RT   "Polycomb-like genes are necessary for specification of dopaminergic and
RT   serotonergic neurons in Caenorhabditis elegans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:852-857(2007).
CC   -!- FUNCTION: Probably acts synergistically with sop-2 to maintain the
CC       transcriptionally repressive state of homeotic genes in order to
CC       regulate various neurogenic identities. Specification of some neuronal
CC       identities also involves expression of non-Hox genes. Specifies
CC       dopaminergic and serotonergic neuronal cell fate, and regulates
CC       neurotransmitter choice and axon pathfinding.
CC       {ECO:0000269|PubMed:17215367}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17215367}. Nucleus
CC       {ECO:0000269|PubMed:17215367}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC       {ECO:0000269|PubMed:17215367}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos, larvae and adults.
CC       {ECO:0000269|PubMed:17215367}.
CC   -!- DISRUPTION PHENOTYPE: Worms exhibit ectopic expression of Hox genes and
CC       homeotic transformations. Mutants are also long and exhibit defects in
CC       distal tip cell migration. {ECO:0000269|PubMed:17215367}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO080330; CCD62907.1; -; Genomic_DNA.
DR   PIR; T15405; T15405.
DR   RefSeq; NP_508090.2; NM_075689.5.
DR   AlphaFoldDB; Q11193; -.
DR   BioGRID; 45344; 4.
DR   STRING; 6239.C04E7.2; -.
DR   EPD; Q11193; -.
DR   PaxDb; Q11193; -.
DR   PeptideAtlas; Q11193; -.
DR   EnsemblMetazoa; C04E7.2.1; C04E7.2.1; WBGene00015429.
DR   GeneID; 180391; -.
DR   KEGG; cel:CELE_C04E7.2; -.
DR   UCSC; C04E7.2; c. elegans.
DR   CTD; 180391; -.
DR   WormBase; C04E7.2; CE40683; WBGene00015429; sor-3.
DR   eggNOG; ENOG502TI3R; Eukaryota.
DR   GeneTree; ENSGT00970000197491; -.
DR   HOGENOM; CLU_513128_0_0_1; -.
DR   InParanoid; Q11193; -.
DR   OMA; IPEYSAC; -.
DR   OrthoDB; 1531702at2759; -.
DR   PRO; PR:Q11193; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00015429; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IMP:WormBase.
DR   GO; GO:0007411; P:axon guidance; IMP:WormBase.
DR   GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:WormBase.
DR   GO; GO:0002119; P:nematode larval development; IGI:WormBase.
DR   GO; GO:0048665; P:neuron fate specification; IMP:WormBase.
DR   GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR   InterPro; IPR004092; Mbt.
DR   Pfam; PF02820; MBT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..531
FT                   /note="Sop-2-related protein 3"
FT                   /id="PRO_0000065135"
SQ   SEQUENCE   531 AA;  61730 MW;  1BD758C85863B14B CRC64;
     MDTTNQSEDI KPCDSDLMES ILMFDEPISD ILAHNKLWIS HARTRSNFFP QEGRHISNQH
     TEAATSLKMW MLSKNLVVIV KRKDDIFPCK ILTRNPENLF VARFLESGKE KHIQVEYSDI
     IMTRSELEKA LPLCQHLIPA RNWDDFYIIR DFEKATPYFE QGLSALVKPG QQFELQLEDA
     PDFYVMATVV KNYRGFLLVE YQNFKRWIHM LSPYCHEIGW GKNEKQEYLK RGPYNRHMNV
     DLVAGLVKQS TNQKLGAVPE IVFRNNCPVP HRIPEYSACV YLDLDQKRFY FAHKVTTKTC
     RNNRHFFNIS IGKNLVTSKQ NNRPYEFHVY HPRILPYSVA KRMEVQIILP PDVKLLPDES
     NLDGYLRTYC NPCDKHKTSD RVQPSPKIAK KKNGPLLLDD TPDAMFRSRP LLGDNIGAHK
     EWTNFMNHIP DYKRKDLLKS MDTLKFCEIF RPTPTGALQL TAAEVTGQQE CMLRLKVSGE
     DEPVYIHNAD PHLYHLGACL DMELAINFHG EFFDEKPLKK NKNANNGFSS F