SORC3_HUMAN
ID SORC3_HUMAN Reviewed; 1222 AA.
AC Q9UPU3; Q5VXF9; Q9NQJ2;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=VPS10 domain-containing receptor SorCS3;
DE Flags: Precursor;
GN Name=SORCS3; Synonyms=KIAA1059;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11499680; DOI=10.1007/s004390100504;
RA Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C.;
RT "The genes for the human VPS10 domain-containing receptors are large and
RT contain many small exons.";
RL Hum. Genet. 108:529-536(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- INTERACTION:
CC Q9UPU3; P54253: ATXN1; NbExp=3; IntAct=EBI-7484437, EBI-930964;
CC Q9UPU3; Q9BRQ0: PYGO2; NbExp=3; IntAct=EBI-7484437, EBI-932471;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB028982; BAA83011.2; -; mRNA.
DR EMBL; AL161646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL358949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS7558.1; -.
DR RefSeq; NP_055793.1; NM_014978.2.
DR AlphaFoldDB; Q9UPU3; -.
DR SMR; Q9UPU3; -.
DR BioGRID; 116635; 4.
DR IntAct; Q9UPU3; 3.
DR MINT; Q9UPU3; -.
DR STRING; 9606.ENSP00000358715; -.
DR TCDB; 9.A.63.1.4; the retromer-dependent vacuolar protein sorting (r-vps) family.
DR GlyGen; Q9UPU3; 8 sites.
DR iPTMnet; Q9UPU3; -.
DR PhosphoSitePlus; Q9UPU3; -.
DR BioMuta; SORCS3; -.
DR DMDM; 27151703; -.
DR EPD; Q9UPU3; -.
DR MassIVE; Q9UPU3; -.
DR PaxDb; Q9UPU3; -.
DR PeptideAtlas; Q9UPU3; -.
DR PRIDE; Q9UPU3; -.
DR ProteomicsDB; 85445; -.
DR Antibodypedia; 31628; 59 antibodies from 15 providers.
DR DNASU; 22986; -.
DR Ensembl; ENST00000369701.8; ENSP00000358715.3; ENSG00000156395.14.
DR GeneID; 22986; -.
DR KEGG; hsa:22986; -.
DR MANE-Select; ENST00000369701.8; ENSP00000358715.3; NM_014978.3; NP_055793.1.
DR UCSC; uc001kyi.1; human.
DR CTD; 22986; -.
DR DisGeNET; 22986; -.
DR GeneCards; SORCS3; -.
DR HGNC; HGNC:16699; SORCS3.
DR HPA; ENSG00000156395; Group enriched (adrenal gland, brain).
DR MIM; 606285; gene.
DR neXtProt; NX_Q9UPU3; -.
DR OpenTargets; ENSG00000156395; -.
DR PharmGKB; PA134949387; -.
DR VEuPathDB; HostDB:ENSG00000156395; -.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_010702_0_0_1; -.
DR InParanoid; Q9UPU3; -.
DR OMA; RRNDGNC; -.
DR OrthoDB; 1046610at2759; -.
DR PhylomeDB; Q9UPU3; -.
DR TreeFam; TF324918; -.
DR PathwayCommons; Q9UPU3; -.
DR SignaLink; Q9UPU3; -.
DR BioGRID-ORCS; 22986; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; SORCS3; human.
DR GenomeRNAi; 22986; -.
DR Pharos; Q9UPU3; Tbio.
DR PRO; PR:Q9UPU3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9UPU3; protein.
DR Bgee; ENSG00000156395; Expressed in ventricular zone and 85 other tissues.
DR ExpressionAtlas; Q9UPU3; baseline and differential.
DR Genevisible; Q9UPU3; HS.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0008188; F:neuropeptide receptor activity; NAS:UniProtKB.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR GO; GO:1900452; P:regulation of long-term synaptic depression; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF49299; SSF49299; 2.
DR PROSITE; PS50093; PKD; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..1222
FT /note="VPS10 domain-containing receptor SorCS3"
FT /id="PRO_0000033174"
FT TOPO_DOM 34..1125
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1147..1222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 231..242
FT /note="BNR 1"
FT REPEAT 279..290
FT /note="BNR 2"
FT REPEAT 320..331
FT /note="BNR 3"
FT REPEAT 515..526
FT /note="BNR 4"
FT REPEAT 592..603
FT /note="BNR 5"
FT REPEAT 634..645
FT /note="BNR 6"
FT DOMAIN 827..917
FT /note="PKD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT REGION 40..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 456
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 789
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 800
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 840
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 932
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 953
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1065
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1222 AA; 135755 MW; 57671F993B09D597 CRC64;
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA SRPPALSPLS
PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE MQVEAGGTSP AGERRGRGIP
APAKLGGARR SRRAQPPITQ ERGDAWATAP ADGSRGSRPL AKGSREEVKA PRAGGSAAED
LRLPSTSFAL TGDSAHNQAM VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY
EKLNDKVGLK TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK EADLVHMEVR
TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY IFIQVTTSGR ASYYVSYRRE
AFAQIKLPKY SLPKDMHIIS TDENQVFAAV QEWNQNDTYN LYISDTRGIY FTLAMENIKS
SRGLMGNIII ELYEVAGIKG IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH
CLLPFCSLHL HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS VPLFVDGALV
EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED YQTWHLLNQG EPCVMGERKI
FKKRKPGAQC ALGRDHSGSV VSEPCVCANW DFECDYGYER HGESQCVPAF WYNPASPSKD
CSLGQSYLNS TGYRRIVSNN CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN
ATFIILMEEG DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW FGNSTKPLIT
LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF QSQLLSFSPN LDYHNPDIPE
WRKDIGNVIK RALVKVTSVP EDQILIAVFP GLPTSAELFI LPPKNLTERR KGNEGDLEQI
VETLFNALNQ NLVQFELKPG VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV
FLIYKFKRKI PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
IGGIATIANS ESTKEIPNCT SV
