SORC3_MOUSE
ID SORC3_MOUSE Reviewed; 1219 AA.
AC Q8VI51; Q9CTR4;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=VPS10 domain-containing receptor SorCS3;
DE Flags: Precursor;
GN Name=Sorcs3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Hermey G., Rezgaoui M., Hermans-Borgmeyer I.;
RT "Cloning of a novel vps10 domain receptor.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 244-261, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1191-1219.
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000305}.
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DR EMBL; AF276314; AAL36983.1; -; mRNA.
DR EMBL; AK020713; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS38020.1; -.
DR RefSeq; NP_079972.1; NM_025696.3.
DR AlphaFoldDB; Q8VI51; -.
DR SMR; Q8VI51; -.
DR STRING; 10090.ENSMUSP00000077919; -.
DR GlyConnect; 2825; 3 N-Linked glycans (2 sites).
DR GlyGen; Q8VI51; 7 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; Q8VI51; -.
DR PhosphoSitePlus; Q8VI51; -.
DR MaxQB; Q8VI51; -.
DR PaxDb; Q8VI51; -.
DR PRIDE; Q8VI51; -.
DR ProteomicsDB; 258710; -.
DR Antibodypedia; 31628; 59 antibodies from 15 providers.
DR DNASU; 66673; -.
DR Ensembl; ENSMUST00000078880; ENSMUSP00000077919; ENSMUSG00000063434.
DR GeneID; 66673; -.
DR KEGG; mmu:66673; -.
DR UCSC; uc008hvx.1; mouse.
DR CTD; 22986; -.
DR MGI; MGI:1913923; Sorcs3.
DR VEuPathDB; HostDB:ENSMUSG00000063434; -.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_010702_0_0_1; -.
DR InParanoid; Q8VI51; -.
DR OMA; RRNDGNC; -.
DR OrthoDB; 1046610at2759; -.
DR PhylomeDB; Q8VI51; -.
DR TreeFam; TF324918; -.
DR BioGRID-ORCS; 66673; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Sorcs3; mouse.
DR PRO; PR:Q8VI51; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VI51; protein.
DR Bgee; ENSMUSG00000063434; Expressed in dorsal lateral geniculate nucleus and 103 other tissues.
DR ExpressionAtlas; Q8VI51; baseline and differential.
DR Genevisible; Q8VI51; MM.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IDA:SynGO.
DR GO; GO:0014069; C:postsynaptic density; IDA:MGI.
DR GO; GO:0007612; P:learning; IMP:MGI.
DR GO; GO:0007613; P:memory; IMP:MGI.
DR GO; GO:1900452; P:regulation of long-term synaptic depression; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF49299; SSF49299; 2.
DR PROSITE; PS50093; PKD; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..1219
FT /note="VPS10 domain-containing receptor SorCS3"
FT /id="PRO_0000033175"
FT TOPO_DOM 34..1122
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1123..1143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1144..1219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 228..239
FT /note="BNR 1"
FT REPEAT 276..287
FT /note="BNR 2"
FT REPEAT 317..328
FT /note="BNR 3"
FT REPEAT 512..523
FT /note="BNR 4"
FT REPEAT 589..600
FT /note="BNR 5"
FT REPEAT 631..642
FT /note="BNR 6"
FT DOMAIN 824..914
FT /note="PKD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT REGION 71..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 786
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 797
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 837
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 950
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1219 AA; 135985 MW; ABB3278A2EFEC7C4 CRC64;
MEAAGTERPA GWPGAPLART GLLLLSTWVL AGAEITWGAT GGPGRLVSPA SRPPVLPPLL
PRAAENRWPE ELASARRAAA PRRRSRLEPL SQASRGEIRT EAAGMSPEGA RWVPGIPSPS
QAGSARRTRR AQPPSPLERG DSWATALADG AKGSRPHTKG SREEVRATRT GGASTEELRL
PSTSFALTGD SAHNQAMVHW SGHNSSVILI LTKLYDFNLG SVTESSLWRS VDYGATYEKL
NDKVGLKTVL SYLYVNPTNK RKIMLLSDPE MESSVLISSD EGATYQKYRL TFYIQSLLFH
PKQEDWVLAY SLDQKLYSSM DFGRRWQLMH ERITPNRFYW SVSGLDKEAD LVHMEVRTAD
GYAHYLTCRI QECAETTRSG PFARSIDISS LVVQDEYIFI QVTIGGRASY YVSYRREAFA
QIKLPKYSLP KDMHIISTDE NQVFAAVQEW NQNDTYNLYI SDTRGIYFTL AMENIKSSRG
LMGNIIIELY EVAGIKGIFL ANKKVDDQVK TYITYNKGRD WRLLQAPDVD LRGSPVHCLL
PFCSLHLHLQ LSENPYSSGR ISSKDTAPGL VVATGNIGSE LSYTDIGVFI SSDGGNTWRQ
IFDEEYNVWF LDWGGALVAM KHTPLPVRHL WVSFDEGHSW DKYGFTLLPL FVDGALVEAG
VETHIMTVFG HFSLRSEWQL VKVDYKSIFS RRCTKEDFET WHLLNQGEPC VMGERKIFKK
RKPGAQCALG REYSGSVVSE PCVCADWDFE CDYGYERHGE SQCVPAFWYN PASPSKDCSL
GQSYLNSTGY RRIVSNNCTD GLRDKYSAKT QLCPGKAPRG LHVVTTDGRL VAEQGHNATF
IILMEEGDLQ RTNIQLDFGD GVAVSYANFS PIEDGIRHVY KSAGIFQVTA YAENNLGSDT
AFLFLHVVCP VEHVHLRVPF VAIRNKDVNI SAVVWPSQLG TLTYFWWFGN STKPLITLDS
SISFTFLAEG TNTITVQVAA GNALIQDTKE IAVHEYFQSQ LLSFSPNLDY HNPDIPEWRQ
DIGNVIKRAL IKVTSVPEDQ ILVAVFPGLP TSAELFILPP KNLTERRKGH EGDLEQIVET
LFNALNQNLV QFELKPGVQV IVYVTQLTLA PLVDSSAGHS SSAMLMLLSV VFVGLAVFLI
YKFKRKIPWI NIYAQVQHDK EQEMIGSVSQ SENAPKITLS DFTEPEELLD KELDTRVIGS
IATIASSEST KEIPNCTSV
