ID   SORC_KLEPN              Reviewed;         315 AA.
AC   P37078;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Sorbitol operon regulator;
DE   AltName: Full=Sor operon activator;
GN   Name=sorC;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=7947968; DOI=10.1016/0167-4838(94)90124-4;
RA   Wehmeier U.F., Lengeler J.W.;
RT   "Sequence of the sor-operon for L-sorbose utilization from Klebsiella
RT   pneumoniae KAY2026.";
RL   Biochim. Biophys. Acta 1208:348-351(1994).
CC   -!- FUNCTION: Positively regulates, in the presence of L-sorbose, and
CC       negatively regulates, in the absence of L-sorbose, the transcription of
CC       the sor operon.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X66059; CAA46855.1; -; Genomic_DNA.
DR   PIR; S50185; S50185.
DR   PDB; 2W48; X-ray; 3.20 A; A/B/C/D=1-315.
DR   PDBsum; 2W48; -.
DR   AlphaFoldDB; P37078; -.
DR   SMR; P37078; -.
DR   EvolutionaryTrace; P37078; -.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR025246; IS30-like_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   Pfam; PF13936; HTH_38; 1.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Sorbitol operon regulator"
FT                   /id="PRO_0000062789"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   HELIX           6..18
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           24..30
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           35..47
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          50..55
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           61..73
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          76..81
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          84..86
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           90..106
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          112..115
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           119..125
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          138..143
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           152..154
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           156..166
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          176..179
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           183..191
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           193..202
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          206..210
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          219..221
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           223..227
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           230..237
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          240..244
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          247..250
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           261..263
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           269..273
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          275..281
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           285..287
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           288..296
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   STRAND          301..306
FT                   /evidence="ECO:0007829|PDB:2W48"
FT   HELIX           307..314
FT                   /evidence="ECO:0007829|PDB:2W48"
SQ   SEQUENCE   315 AA;  35104 MW;  0C16EF4F1032D48A CRC64;
     MENSDDIRLI VKIAQLYYEQ DMTQAQIARE LGIYRTTISR LLKRGREQGI VTIAINYDYN
     ENLWLEQQLK QKFGLKEAVV ASSDGLLEEE QLSAMGQHGA LLVDRLLEPG DIIGFSWGRA
     VRSLVENLPQ RSQSRQVICV PIIGGPSGKL ESRYHVNTLT YGAAARLKAE SHLADFPALL
     DNPLIRNGIM QSQHFKTISS YWDSLDVALV GIGSPAIRDG ANWHAFYGSE ESDDLNARHV
     AGDICSRFYD INGGLVDTNM SEKTLSIEMA KLRQARYSIG IAMGEEKYSG ILGALHGRYI
     NCLVTNRETA ELLLK