SORR1_HYPJQ
ID SORR1_HYPJQ Reviewed; 685 AA.
AC G0R6T4;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Sorbicillinoid biosynthetic cluster transcription factor sor4 {ECO:0000303|PubMed:28010735};
DE AltName: Full=Sorbicillinoid biosynthetic cluster protein 4 {ECO:0000303|PubMed:28010735};
GN Name=sor4 {ECO:0000303|PubMed:28010735};
GN Synonyms=ypr1 {ECO:0000303|PubMed:29104566}; ORFNames=TRIREDRAFT_102499;
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000312|Proteomes:UP000008984};
RN [1] {ECO:0000312|EMBL:EGR52693.1, ECO:0000312|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000312|EMBL:EGR52693.1,
RC ECO:0000312|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
RN [2]
RP IDENTIFICATION.
RX PubMed=28010735; DOI=10.1186/s12862-016-0834-6;
RA Druzhinina I.S., Kubicek E.M., Kubicek C.P.;
RT "Several steps of lateral gene transfer followed by events of 'birth-and-
RT death' evolution shaped a fungal sorbicillinoid biosynthetic gene
RT cluster.";
RL BMC Evol. Biol. 16:269-269(2016).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29104566; DOI=10.3389/fmicb.2017.02037;
RA Derntl C., Guzman-Chavez F., Mello-de-Sousa T.M., Busse H.J.,
RA Driessen A.J.M., Mach R.L., Mach-Aigner A.R.;
RT "In vivo study of the sorbicillinoid gene cluster in Trichoderma reesei.";
RL Front. Microbiol. 8:2037-2037(2017).
CC -!- FUNCTION: Transcription factor that acts as the main regulator of the
CC gene cluster that mediates the biosynthesis of sorbicillinoids, a
CC diverse group of yellow secondary metabolites that restrict growth of
CC competing pathogenic fungi but not of bacteria (PubMed:29104566).
CC {ECO:0000305|PubMed:29104566}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Impairs the production of sorbicillinol
CC (PubMed:29104566). {ECO:0000269|PubMed:29104566}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL985056; EGR52693.1; -; Genomic_DNA.
DR RefSeq; XP_006961563.1; XM_006961501.1.
DR AlphaFoldDB; G0R6T4; -.
DR EnsemblFungi; EGR52693; EGR52693; TRIREDRAFT_102499.
DR GeneID; 18480410; -.
DR KEGG; tre:TRIREDRAFT_102499; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_102499; -.
DR eggNOG; ENOG502QVC1; Eukaryota.
DR HOGENOM; CLU_011017_3_1_1; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 4: Predicted;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..685
FT /note="Sorbicillinoid biosynthetic cluster transcription
FT factor sor4"
FT /id="PRO_0000443839"
FT DNA_BIND 22..49
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 75309 MW; 1166DF95AE7675B4 CRC64;
MGSSATATTT GESTRQQPGL ACEECRRRKA RCDRVRPKCG ICADSGRNCV VLDKRSQRGP
KKGQLKDLRS RLMLLEQRLV GQNDAPSLPQ ERDSLGCPTP SEKVSPEGDL VSSRASTDIG
LDTCMGSTAG AFALFGSTSG SDKMPPLTPD LSTASTANSM AACICKGWQT EPAMFSTSPF
PQIPLTPQST TAPSRMPSIS LAAADPIMPD VRVHPFAPMV HKRRYYAWAS DPNASPARTA
LRSAMRTIAS AMSPQFCDIG HVMYASTRRM LETQDACPET GLPWMTRLKP PHEQRKMHHE
RIQAWLLLAY YDVLRKSEHQ AFITARRAFR LLRLSGLCEM DIDAYSGRQG DVATCTPPAE
TTWNMQMCSS ENGADEAVLQ QDWISVEERR RTVWSAFLLD RLSTMVNDQP TMLMEEAVTK
PHACTFSWYF SADLPISNQF YTRLPMSEAE FQSGTQEPVS QMGFLIEATD GIKASNSIQP
LPPFAHCVVV ANLFARCMTH CKMAMQSPPM SAPEAHDFWI RHQWLASAAA NACESTETRC
DPMLVFTRIL AYSASLSLCS TANATSWQTL DHHLMAMACK PAAHQAASEV VRIIKTAPRI
AFFKMHPFFP NAIALVTSFL NADVPYLPST RGGNAMDAIQ ERQDAVNELL AALRRSSQVN
NLAAELLCKL ELDIGQAASD GSIYG
