ID   SORR1_PENRW             Reviewed;         620 AA.
AC   B6HN75;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Sorbicillinoid biosynthetic cluster transcription factor 1 {ECO:0000303|PubMed:28618182};
GN   Name=sorR1 {ECO:0000303|PubMed:28618182}; ORFNames=Pc21g05050;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28618182; DOI=10.1111/1751-7915.12736;
RA   Guzman-Chavez F., Salo O., Nygaard Y., Lankhorst P.P., Bovenberg R.A.L.,
RA   Driessen A.J.M.;
RT   "Mechanism and regulation of sorbicillin biosynthesis by Penicillium
RT   chrysogenum.";
RL   Microb. Biotechnol. 10:958-968(2017).
CC   -!- FUNCTION: Transcription factor that acts as the main regulator of the
CC       gene cluster that mediates the biosynthesis of sorbicillinoids, a
CC       diverse group of yellow secondary metabolites that restrict growth of
CC       competing pathogenic fungi but not of bacteria (PubMed:28618182).
CC       {ECO:0000269|PubMed:28618182}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes the expression of the entire
CC       sorbicillin biosynthesis gene cluster, and consequently, the production
CC       of all sorbicillinoid-related compounds (PubMed:28618182).
CC       {ECO:0000269|PubMed:28618182}.
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DR   EMBL; AM920436; CAP95402.1; -; Genomic_DNA.
DR   RefSeq; XP_002567551.1; XM_002567505.1.
DR   AlphaFoldDB; B6HN75; -.
DR   EnsemblFungi; CAP95402; CAP95402; PCH_Pc21g05050.
DR   GeneID; 8313802; -.
DR   KEGG; pcs:Pc21g05050; -.
DR   VEuPathDB; FungiDB:PCH_Pc21g05050; -.
DR   eggNOG; ENOG502SH49; Eukaryota.
DR   HOGENOM; CLU_011017_3_1_1; -.
DR   OMA; EWPLTLQ; -.
DR   OrthoDB; 455010at2759; -.
DR   BioCyc; PCHR:PC21G05050-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c21.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..620
FT                   /note="Sorbicillinoid biosynthetic cluster transcription
FT                   factor 1"
FT                   /id="PRO_0000443838"
FT   DNA_BIND        10..37
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          285..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  69538 MW;  3FF55FBCD9E5513A CRC64;
     MRRQQSGLAC EECRRRKARC DRVRPQCGIC ADAGRTCIVV DKRSPRGPKK GQLKDLRYRL
     DGTIGCDMDE LQMLNFASSE SISASDGQEA IDWTLAYDCR EERSGTWNHL DISNPRPCII
     TPISPIQTSA SEMTPKGELD MSDLMQADLD LLYFERVHPI VPMIHKRRYL SWANEKTVSP
     ARACLRSAMR TIAAAMSAQF CAFSDKLYAC TRSMLEMQDV QGENGLPWMT TTRASRRRIE
     HEMIQAWLLL AHCEFLRKPE QDALLASTRA VRLLQLSRLF DIDMHDDETS PNENSGSCPS
     VSPSTTQNLP DEAWIETEEK RRTLWTAFVL DCLSSMLSDR PSMLHEEMIN TRLPMPERDF
     QGGQRPTPMG FLPETMGKTG DCETLSSFAQ CVVLANLFGR CIAHRRLAQS VSFPESGSES
     KSRQFWMRHE WLAAAAAHAT RTMPPTQAPN ECKSETTKCD PLAAFNRILA YSACISLSET
     AEARAWETLD DHTLALSYRQ VASQAAYEIA LLIQKAPRIA FFKMHPVLPN AIYLAARFLR
     TTTPHFATPA EHDHNSIHHL LVALGYLSSV NNLARDLLVK AEADVGKSAR IATEVTGSNW
     DALMGDTSRH IGMMETSISV