ID   SORR2_PENRW             Reviewed;         684 AA.
AC   B6HNK4;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Sorbicillinoid biosynthetic cluster transcription factor 2 {ECO:0000303|PubMed:28618182};
GN   Name=sorR2 {ECO:0000303|PubMed:28618182}; ORFNames=Pc21g05090;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28618182; DOI=10.1111/1751-7915.12736;
RA   Guzman-Chavez F., Salo O., Nygaard Y., Lankhorst P.P., Bovenberg R.A.L.,
RA   Driessen A.J.M.;
RT   "Mechanism and regulation of sorbicillin biosynthesis by Penicillium
RT   chrysogenum.";
RL   Microb. Biotechnol. 10:958-968(2017).
CC   -!- FUNCTION: Transcription factor that acts in concert with sorR1 which is
CC       a transcriptional activator of the gene cluster that mediates the
CC       biosynthesis of sorbicillinoids, a diverse group of yellow secondary
CC       metabolites that restrict growth of competing pathogenic fungi but not
CC       of bacteria (PubMed:28618182). {ECO:0000269|PubMed:28618182}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Has low impact on expression of the sorbicillin
CC       biosynthesis gene cluster but, except for very low levels of
CC       dihydrosorbicillinol, impairs the production of sorbicillinoids
CC       (PubMed:28618182). {ECO:0000269|PubMed:28618182}.
CC   -!- CAUTION: Due to a highly divergent N-terminal sequence, the DNA-binding
CC       zinc finger could not be predicted. {ECO:0000305}.
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DR   EMBL; AM920436; CAP95406.1; -; Genomic_DNA.
DR   RefSeq; XP_002567555.1; XM_002567509.1.
DR   AlphaFoldDB; B6HNK4; -.
DR   EnsemblFungi; CAP95406; CAP95406; PCH_Pc21g05090.
DR   GeneID; 8313806; -.
DR   KEGG; pcs:Pc21g05090; -.
DR   VEuPathDB; FungiDB:PCH_Pc21g05090; -.
DR   eggNOG; ENOG502RBGV; Eukaryota.
DR   HOGENOM; CLU_008511_3_1_1; -.
DR   OMA; CLMLMNR; -.
DR   OrthoDB; 1072777at2759; -.
DR   BioCyc; PCHR:PC21G05090-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c21.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   SMART; SM00906; Fungal_trans; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..684
FT                   /note="Sorbicillinoid biosynthetic cluster transcription
FT                   factor 2"
FT                   /id="PRO_0000443840"
FT   REGION          114..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  76675 MW;  7135E7FB69B09F89 CRC64;
     MENGCTSHWL LSRIAGSESR LANNRAFRCG SIEKAASYLI GELLIINQAE AKSNKRLPKF
     VHKADTYHKA CARCKARGKT CAYGQGAVEK QTVHKPRGQA SSVHMPVPML VPPISSAPSL
     ETPPESVAAS PPTVDSIPVS HHVNEDPEAE PDLEKNRAYY TAHGRFAGQV AAAINERAGL
     IPATCNQVPL VDAPLFGDLN LPSQSCALSS STELPPRAYA DQLIDIYWQH VDPMEPVLDR
     QRFLENYEKA YSTPITPLCA DYDLWLGILN VVFALAVQRQ ELNPLHQRNE EANRFFQRAW
     VLLPAESMLW KPGSLELVQC LMLMNRYLHC TNNQQKTWTT AGLAMRIAQS MCCHLTETPL
     LKGSSDDKAL KQKVWASCVA LDRCISWSLG KTSALVLIPS PPPSSPQQLG ENAMHDTLGL
     RLHEIGNQIQ LAQIQNRTSL AARFRPPLLS QQDEYHNAAL QLDACLQDWE NSIPSDWQPR
     NLRMVTDRSS RAERYLLHLR YLHHRIFLYR PMLARFYAMK PDTQPLHKSP SLSHRLLRES
     ASMCIEAAQQ VASLVNETLE PDEPIGLLPW WYRIYYLHIA GANFLAAMFR SELFTDSVSQ
     SWESVMLALR AHEHLSPYVQ QCLWTFETLA ARITGKPYPS MDGGGCGLMV DGSSGVSFDD
     IFKDINFDFD NFIFGPEDFG EGLV