SORT_PENRW
ID SORT_PENRW Reviewed; 522 AA.
AC B6HNK5;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Major facilitator-type transporter sorT {ECO:0000303|PubMed:29104566};
DE AltName: Full=Sorbicillinoid biosynthetic cluster transporter {ECO:0000303|PubMed:29104566};
GN Name=sorT {ECO:0000303|PubMed:28618182}; ORFNames=Pc21g05100;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
RN [2]
RP FUNCTION.
RX PubMed=29104566; DOI=10.3389/fmicb.2017.02037;
RA Derntl C., Guzman-Chavez F., Mello-de-Sousa T.M., Busse H.J.,
RA Driessen A.J.M., Mach R.L., Mach-Aigner A.R.;
RT "In vivo study of the sorbicillinoid gene cluster in Trichoderma reesei.";
RL Front. Microbiol. 8:2037-2037(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28618182; DOI=10.1111/1751-7915.12736;
RA Guzman-Chavez F., Salo O., Nygaard Y., Lankhorst P.P., Bovenberg R.A.L.,
RA Driessen A.J.M.;
RT "Mechanism and regulation of sorbicillin biosynthesis by Penicillium
RT chrysogenum.";
RL Microb. Biotechnol. 10:958-968(2017).
CC -!- FUNCTION: Major facilitator-type transporter; part of the gene cluster
CC that mediates the biosynthesis of sorbicillinoids, a diverse group of
CC yellow secondary metabolites that restrict growth of competing
CC pathogenic fungi but not of bacteria (PubMed:29104566).
CC {ECO:0000305|PubMed:29104566}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: The production of sorbicillinoids shifts mostly
CC towards tetrahydrobisvertinolon (PubMed:28618182).
CC {ECO:0000269|PubMed:28618182}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM920436; CAP95407.1; -; Genomic_DNA.
DR RefSeq; XP_002567556.1; XM_002567510.1.
DR AlphaFoldDB; B6HNK5; -.
DR EnsemblFungi; CAP95407; CAP95407; PCH_Pc21g05100.
DR GeneID; 8313807; -.
DR KEGG; pcs:Pc21g05100; -.
DR VEuPathDB; FungiDB:PCH_Pc21g05100; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_11_6_1; -.
DR OMA; AMPIVYN; -.
DR OrthoDB; 540452at2759; -.
DR BioCyc; PCHR:PC21G05100-MON; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..522
FT /note="Major facilitator-type transporter sorT"
FT /id="PRO_0000443847"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 56970 MW; A0B1A1D6E43A786C CRC64;
MSHTEPKAPV NTGEVENGHL YDGSGTEDDP FIVEFQKDDP GNPMNWGQSR KWFIAAIATL
SVFAVTFTSS AYSVSANEVF KDFDISTEVF IVGLSLFVLG FAIGPAVWAN IGLRSELYGR
QILWIITHIA MVAFLGGSAG SQNVATLLIL RFFAGTFGGS PLVNSGGTIA DLFPPAQRGL
ALTIYCVAPF LGPILGPIVG GFVSESVGWR WVQGVCVIFI GVVGILGIVF IPETYGPVLL
QRRTHQLAKA DGKIYVSVLE KNQGKKLPSE VFKRALFRPW IFLFLEPIVL IASVYMAIIY
GTVYMFMGAM PIVYNEDRGW SVGIGGLAFL GIAVGIIFGL VYAIWDNNVR YMKLFAAKSA
NPESRLPPAI VGGVALPIGM FAFAWTNYPS IHWSVSIILS APFGFGCVLV ILPIMNYLID
TYTIYAASVL AAAAIFRSVV GAVFPLFTTQ MYHNLGIHWA SSIPAFLTLL CMPFPLIMYR
YGEAVRMKCK YSFEAAEMMR KMQLQQTAAA TTTEKDKDSS SE
