ID   SOR_SPOSM               Reviewed;          49 AA.
AC   P0DSO7;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   31-JUL-2019, sequence version 1.
DT   26-FEB-2020, entry version 5.
DE   RecName: Full=Soritesidine {ECO:0000303|PubMed:30965587};
DE            Short=SOR {ECO:0000303|PubMed:30965587};
DE   Flags: Fragments;
OS   Spongosorites sp. (strain QM G324170) (Okinawan marine Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC   Halichondriidae; Spongosorites; unclassified Spongosorites.
OX   NCBI_TaxID=2582856;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX   PubMed=30965587; DOI=10.3390/md17040216;
RA   Sakai R., Tanano K., Ono T., Kitano M., Iida Y., Nakano K., Jimbo M.;
RT   "Soritechodesidine, a novel proteinous toxin from the Okinawan marine
RT   sponge Spongosorites sp.";
RL   Mar. Drugs 17:1-15(2019).
CC   -!- FUNCTION: Very potent toxin that exhibits a wide range of toxicities
CC       over various organisms and cells including brine shrimp larvae (Artemia
CC       salina), sea hare eggs (Aplysia kurodai), mice, and cultured mammalian
CC       cells (PubMed:30965587). A SOR-containing fraction cleaves plasmid DNA
CC       in a bivalent metal ion dependent manner suggesting genotoxicity of SOR
CC       (PubMed:30965587). {ECO:0000269|PubMed:30965587}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30965587}.
CC   -!- MASS SPECTROMETRY: Mass=108.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:30965587};
CC   -!- TOXIC DOSE: LD(50) is 0.287 ug/kg by intracerebroventricular injection
CC       into mice (PubMed:30965587), when observation is prolonged over 48-54
CC       hours after injection. LD(50) is 0.34 ug/mL when injected into brine
CC       shrimp (PubMed:30965587). {ECO:0000269|PubMed:30965587}.
CC   -!- MISCELLANEOUS: Does not show any hemagglutinating or hemolytic activity
CC       against rabbit erythrocytes (PubMed:30965587). Does not show
CC       antimicrobial activity against both Gram-positive and -negative
CC       bacteria (PubMed:30965587). {ECO:0000269|PubMed:30965587}.
CC   -!- CAUTION: About 18 sequence fragments were determined for this protein.
CC       Only the 2 longest are indicated here. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Toxin.
FT   CHAIN           1..>49
FT                   /note="Soritesidine"
FT                   /evidence="ECO:0000269|PubMed:30965587"
FT                   /id="PRO_0000447634"
FT   NON_CONS        25..26
FT   NON_TER         49
SQ   SEQUENCE   49 AA;  5300 MW;  5C380188106F1F7A CRC64;
     KLGDQRQIDI ASWNTFDFGG VXKANANTGI GNVVIERTDN PNTVPYIPA