SOS2_HUMAN
ID SOS2_HUMAN Reviewed; 1332 AA.
AC Q07890; B7ZKT6; D3DSB4; Q15503; Q17RN1;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 194.
DE RecName: Full=Son of sevenless homolog 2;
DE Short=SOS-2;
GN Name=SOS2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=8493579; DOI=10.1126/science.8493579;
RA Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H.,
RA Bar-Sagi D.;
RT "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to
RT GRB2.";
RL Science 260:1338-1343(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2).
RC TISSUE=Placenta;
RA Fath I., Apiou F., Dutrillaux B., Tocque B.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INVOLVEMENT IN NS9, VARIANTS NS9 LYS-267; LYS-310; HIS-334; SER-376 AND
RP LEU-1092, AND VARIANTS ALA-449 AND ASN-952.
RX PubMed=25795793; DOI=10.1136/jmedgenet-2015-103018;
RA Yamamoto G.L., Aguena M., Gos M., Hung C., Pilch J., Fahiminiya S.,
RA Abramowicz A., Cristian I., Buscarilli M., Naslavsky M.S., Malaquias A.C.,
RA Zatz M., Bodamer O., Majewski J., Jorge A.A., Pereira A.C., Kim C.A.,
RA Passos-Bueno M.R., Bertola D.R.;
RT "Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.";
RL J. Med. Genet. 52:413-421(2015).
CC -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP.
CC {ECO:0000250|UniProtKB:Q62245}.
CC -!- INTERACTION:
CC Q07890; P00519: ABL1; NbExp=2; IntAct=EBI-298181, EBI-375543;
CC Q07890; P46108: CRK; NbExp=3; IntAct=EBI-298181, EBI-886;
CC Q07890; P62993: GRB2; NbExp=11; IntAct=EBI-298181, EBI-401755;
CC Q07890; P16333: NCK1; NbExp=3; IntAct=EBI-298181, EBI-389883;
CC Q07890; Q9UKS6: PACSIN3; NbExp=2; IntAct=EBI-298181, EBI-77926;
CC Q07890; P19174: PLCG1; NbExp=4; IntAct=EBI-298181, EBI-79387;
CC Q07890; Q9Y5X1: SNX9; NbExp=2; IntAct=EBI-298181, EBI-77848;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q07890-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q07890-2; Sequence=VSP_054492;
CC -!- DISEASE: Noonan syndrome 9 (NS9) [MIM:616559]: A form of Noonan
CC syndrome, a disease characterized by short stature, facial dysmorphic
CC features such as hypertelorism, a downward eyeslant and low-set
CC posteriorly rotated ears, and a high incidence of congenital heart
CC defects and hypertrophic cardiomyopathy. Other features can include a
CC short neck with webbing or redundancy of skin, deafness, motor delay,
CC variable intellectual deficits, multiple skeletal defects,
CC cryptorchidism, and bleeding diathesis. Individuals with Noonan
CC syndrome are at risk of juvenile myelomonocytic leukemia, a
CC myeloproliferative disorder characterized by excessive production of
CC myelomonocytic cells. {ECO:0000269|PubMed:25795793}. Note=The disease
CC is caused by variants affecting the gene represented in this entry.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Son of sevenless entry;
CC URL="https://en.wikipedia.org/wiki/Son_of_Sevenless";
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DR EMBL; L13858; AAA35914.1; -; mRNA.
DR EMBL; AL109758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW65727.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW65728.1; -; Genomic_DNA.
DR EMBL; BC143367; AAI43368.1; -; mRNA.
DR EMBL; BC117261; AAI17262.1; -; mRNA.
DR EMBL; L20686; AAA91852.1; -; mRNA.
DR CCDS; CCDS9697.1; -. [Q07890-1]
DR RefSeq; NP_008870.2; NM_006939.3. [Q07890-1]
DR PDB; 6EIE; X-ray; 2.72 A; A=562-1047.
DR PDBsum; 6EIE; -.
DR AlphaFoldDB; Q07890; -.
DR SMR; Q07890; -.
DR BioGRID; 112538; 42.
DR IntAct; Q07890; 33.
DR MINT; Q07890; -.
DR STRING; 9606.ENSP00000216373; -.
DR ChEMBL; CHEMBL4524041; -.
DR iPTMnet; Q07890; -.
DR PhosphoSitePlus; Q07890; -.
DR BioMuta; SOS2; -.
DR DMDM; 223634694; -.
DR CPTAC; CPTAC-1553; -.
DR EPD; Q07890; -.
DR jPOST; Q07890; -.
DR MassIVE; Q07890; -.
DR MaxQB; Q07890; -.
DR PaxDb; Q07890; -.
DR PeptideAtlas; Q07890; -.
DR PRIDE; Q07890; -.
DR ProteomicsDB; 58555; -. [Q07890-1]
DR ProteomicsDB; 7192; -.
DR Antibodypedia; 3885; 165 antibodies from 28 providers.
DR DNASU; 6655; -.
DR Ensembl; ENST00000216373.10; ENSP00000216373.5; ENSG00000100485.12. [Q07890-1]
DR Ensembl; ENST00000543680.5; ENSP00000445328.1; ENSG00000100485.12. [Q07890-2]
DR GeneID; 6655; -.
DR KEGG; hsa:6655; -.
DR MANE-Select; ENST00000216373.10; ENSP00000216373.5; NM_006939.4; NP_008870.2.
DR UCSC; uc001wxs.5; human. [Q07890-1]
DR CTD; 6655; -.
DR DisGeNET; 6655; -.
DR GeneCards; SOS2; -.
DR GeneReviews; SOS2; -.
DR HGNC; HGNC:11188; SOS2.
DR HPA; ENSG00000100485; Low tissue specificity.
DR MalaCards; SOS2; -.
DR MIM; 601247; gene.
DR MIM; 616559; phenotype.
DR neXtProt; NX_Q07890; -.
DR OpenTargets; ENSG00000100485; -.
DR Orphanet; 648; Noonan syndrome.
DR PharmGKB; PA36025; -.
DR VEuPathDB; HostDB:ENSG00000100485; -.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000158324; -.
DR HOGENOM; CLU_002744_0_0_1; -.
DR InParanoid; Q07890; -.
DR OMA; PPPFEWH; -.
DR OrthoDB; 576110at2759; -.
DR PhylomeDB; Q07890; -.
DR TreeFam; TF317296; -.
DR PathwayCommons; Q07890; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-428540; Activation of RAC1.
DR Reactome; R-HSA-8983432; Interleukin-15 signaling.
DR Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR SignaLink; Q07890; -.
DR SIGNOR; Q07890; -.
DR BioGRID-ORCS; 6655; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; SOS2; human.
DR GenomeRNAi; 6655; -.
DR Pharos; Q07890; Tbio.
DR PRO; PR:Q07890; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q07890; protein.
DR Bgee; ENSG00000100485; Expressed in vastus lateralis and 210 other tissues.
DR ExpressionAtlas; Q07890; baseline and differential.
DR Genevisible; Q07890; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:2000973; P:regulation of pro-B cell differentiation; IEA:Ensembl.
DR GO; GO:0033081; P:regulation of T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:Ensembl.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disease variant;
KW Guanine-nucleotide releasing factor; Methylation; Reference proteome.
FT CHAIN 1..1332
FT /note="Son of sevenless homolog 2"
FT /id="PRO_0000068896"
FT DOMAIN 198..388
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 442..546
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 595..739
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 778..1017
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 1018..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1321
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q02384"
FT VAR_SEQ 324..356
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054492"
FT VARIANT 267
FT /note="M -> K (in NS9; dbSNP:rs797045167)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075686"
FT VARIANT 310
FT /note="N -> K (in NS9; unknown pathological significance)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075687"
FT VARIANT 334
FT /note="R -> H (in NS9; unknown pathological significance;
FT dbSNP:rs373233749)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075688"
FT VARIANT 376
FT /note="T -> S (in NS9; dbSNP:rs869320687)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075689"
FT VARIANT 449
FT /note="T -> A (in dbSNP:rs768547025)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075690"
FT VARIANT 483
FT /note="S -> N (in dbSNP:rs17122201)"
FT /id="VAR_054327"
FT VARIANT 508
FT /note="H -> Y (in dbSNP:rs8010237)"
FT /id="VAR_054328"
FT VARIANT 672
FT /note="L -> I (in dbSNP:rs34139502)"
FT /id="VAR_034441"
FT VARIANT 952
FT /note="D -> N (in dbSNP:rs200387871)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075691"
FT VARIANT 1092
FT /note="P -> L (in NS9; unknown pathological significance;
FT dbSNP:rs1442962879)"
FT /evidence="ECO:0000269|PubMed:25795793"
FT /id="VAR_075692"
FT CONFLICT 32
FT /note="E -> V (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="S -> C (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 239..240
FT /note="DI -> VY (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="L -> H (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="S -> T (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 687
FT /note="I -> V (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 696
FT /note="E -> D (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 699
FT /note="F -> Y (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 778
FT /note="H -> D (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 861
FT /note="Q -> R (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 948
FT /note="K -> R (in Ref. 1; AAA35914)"
FT /evidence="ECO:0000305"
FT CONFLICT 999
FT /note="S -> C (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 1032
FT /note="S -> E (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 1042
FT /note="T -> A (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 1112..1114
FT /note="CGS -> LC (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 1159
FT /note="A -> G (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT CONFLICT 1296
FT /note="Q -> E (in Ref. 5; AAA91852)"
FT /evidence="ECO:0000305"
FT TURN 570..572
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 574..576
FT /evidence="ECO:0007829|PDB:6EIE"
FT TURN 581..583
FT /evidence="ECO:0007829|PDB:6EIE"
FT STRAND 584..586
FT /evidence="ECO:0007829|PDB:6EIE"
FT STRAND 599..602
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 604..611
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 619..628
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 629..631
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 635..646
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 655..661
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 670..678
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 680..697
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 700..704
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 706..716
FT /evidence="ECO:0007829|PDB:6EIE"
FT TURN 721..723
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 725..740
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 769..771
FT /evidence="ECO:0007829|PDB:6EIE"
FT TURN 774..776
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 779..795
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 799..801
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 803..808
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 812..815
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 817..839
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 843..863
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 866..876
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 879..882
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 885..889
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 893..916
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 928..941
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 956..970
FT /evidence="ECO:0007829|PDB:6EIE"
FT STRAND 973..975
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 983..990
FT /evidence="ECO:0007829|PDB:6EIE"
FT HELIX 1000..1014
FT /evidence="ECO:0007829|PDB:6EIE"
FT STRAND 1018..1020
FT /evidence="ECO:0007829|PDB:6EIE"
SQ SEQUENCE 1332 AA; 152979 MW; 0D1D4FAB8E37C371 CRC64;
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD
IGLVSLCEDE PSSSGELNYY DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI
EKIFSNISDI HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH YFELLKQLKA
CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD PVCPFYSHQL RSKHLAIKKM
NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR IGAKHERHIF LFDGLMISCK PNHGQTRLPG
YSSAEYRLKE KFVMRKIQIC DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI
SLHYRSTLDR MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE PEPTDADKLA
IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY DFERDLELLE RLESFISSVR
GKAMKKWVES IAKIIRRKKQ AQANGVSHNI TFESPPPPIE WHISKPGQFE TFDLMTLHPI
EIARQLTLLE SDLYRKVQPS ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA
ENFEERVAVL SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG KDLINFSKRR
KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE KEFTDYLFNK SLEIEPRNCK
QPPRFPRKST FSLKSPGIRP NTGRHGSTSG TLRGHPTPLE REPCKISFSR IAETELESTV
SAPTSPNTPS TPPVSASSDL SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS
EEPLIPPPLP PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR DISTCPNSPS
TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP HLPKLPPKTY KRELSHPPLY
RLPLLENAET PQ
