ID   SOS7_SCHPO              Reviewed;         264 AA.
AC   U3H042;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Kinetochore protein Sos7;
DE   AltName: Full=Suppressor of spc7 protein;
GN   Name=sos7; ORFNames=SPAPB17E12.06;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   FUNCTION, SUBUNIT, INTERACTION WITH SPC7, SUBCELLULAR LOCATION, AND
RP   MUTAGENESIS OF ILE-178.
RX   PubMed=22711988; DOI=10.1128/mcb.00212-12;
RA   Jakopec V., Topolski B., Fleig U.;
RT   "Sos7, an essential component of the conserved Schizosaccharomyces pombe
RT   Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore
RT   proteins.";
RL   Mol. Cell. Biol. 32:3308-3320(2012).
CC   -!- FUNCTION: Acts as a component of the NMS (Ndc80-MIND-Spc7) super
CC       complex which has a role in kinetochore function during late meiotic
CC       prophase and throughout the mitotic cell cycle. Essential for
CC       chromosome segregation and bipolar sister chromatid association.
CC       Required for kinetochore targeting of MIND, but not Ndc80 complex
CC       components. {ECO:0000269|PubMed:22711988}.
CC   -!- SUBUNIT: Component of the NMS super complex which consists of mis12,
CC       mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts
CC       (via C-terminus) directly with spc7 (via C-terminus).
CC       {ECO:0000269|PubMed:22711988}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22711988}.
CC       Chromosome, centromere {ECO:0000269|PubMed:22711988}. Chromosome,
CC       centromere, kinetochore {ECO:0000269|PubMed:22711988}.
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DR   EMBL; CU329670; CAO77638.2; -; Genomic_DNA.
DR   RefSeq; XP_004001765.1; XM_004001716.1.
DR   AlphaFoldDB; U3H042; -.
DR   SMR; U3H042; -.
DR   BioGRID; 280478; 4.
DR   STRING; 4896.SPAPB17E12.06.1; -.
DR   PaxDb; U3H042; -.
DR   EnsemblFungi; SPAPB17E12.06.1; SPAPB17E12.06.1:pep; SPAPB17E12.06.
DR   PomBase; SPAPB17E12.06; sos7.
DR   VEuPathDB; FungiDB:SPAPB17E12.06; -.
DR   eggNOG; ENOG502S6XI; Eukaryota.
DR   HOGENOM; CLU_1090528_0_0_1; -.
DR   OMA; DARIMIE; -.
DR   PRO; PR:U3H042; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR   GO; GO:0031617; C:NMS complex; IPI:PomBase.
DR   GO; GO:0005634; C:nucleus; IC:PomBase.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IMP:PomBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051382; P:kinetochore assembly; IBA:GO_Central.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.
DR   GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IC:PomBase.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   GO; GO:1903394; P:protein localization to kinetochore involved in kinetochore assembly; IMP:PomBase.
DR   InterPro; IPR037475; Sos7.
DR   PANTHER; PTHR37329; PTHR37329; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..264
FT                   /note="Kinetochore protein Sos7"
FT                   /id="PRO_0000429002"
FT   COILED          90..236
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         178
FT                   /note="I->N: In sos7-178; temperature-sensitive; increases
FT                   the number of chromosome segregation defects above 34
FT                   degrees Celsius."
FT                   /evidence="ECO:0000269|PubMed:22711988"
SQ   SEQUENCE   264 AA;  30523 MW;  251256789FA14B8D CRC64;
     MDQNKSTQAT GNGKKTEEIN ELLESFIKEG PKLLWGSTNL KYEDQISRSS EHELQQYREL
     FTRLKFSYIE QGTKERYLRA ILDDPPMLVE AEDNEKLETT NSSLKGRLKS EKREVDLLTE
     ELKTTSRELS SNYESVMEEC KNTKSTLSKL ESLESELLKL QQDSSTKTPI LPEVEAAIHD
     LESELNITNE SIETIDGKID NDEKYFIQLT KNLSLLEKEY KIASERSNQI KAAIHTRTPD
     ADAKKQVQNW YTSMLEIYDQ LLQK