ID   SOSB1_XENTR             Reviewed;         203 AA.
AC   Q66K94;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=SOSS complex subunit B1;
DE   AltName: Full=Nucleic acid-binding protein 2;
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2B;
DE   AltName: Full=Sensor of single-strand DNA complex subunit B1;
DE   AltName: Full=Sensor of ssDNA subunit B1;
DE            Short=SOSS-B1;
DE   AltName: Full=Single-stranded DNA-binding protein 1;
GN   Name=nabp2; Synonyms=obfc2b, ssb1; ORFNames=TGas103n10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC       DNA that binds to single-stranded DNA. The SOSS complex associates with
CC       DNA lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of soss-b (soss-
CC       b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip. SOSS
CC       complexes containing soss-b1/nabp2 are more abundant than complexes
CC       containing soss-b2/nabp1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR762209; CAJ81599.1; -; mRNA.
DR   EMBL; BC080502; AAH80502.1; -; mRNA.
DR   RefSeq; NP_001007990.1; NM_001007989.1.
DR   AlphaFoldDB; Q66K94; -.
DR   SMR; Q66K94; -.
DR   STRING; 8364.ENSXETP00000053108; -.
DR   PaxDb; Q66K94; -.
DR   GeneID; 493352; -.
DR   KEGG; xtr:493352; -.
DR   CTD; 79035; -.
DR   Xenbase; XB-GENE-985188; nabp2.
DR   eggNOG; KOG3416; Eukaryota.
DR   HOGENOM; CLU_102724_3_1_1; -.
DR   InParanoid; Q66K94; -.
DR   OrthoDB; 1512483at2759; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024652; Expressed in egg cell and 14 other tissues.
DR   ExpressionAtlas; Q66K94; baseline.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..203
FT                   /note="SOSS complex subunit B1"
FT                   /id="PRO_0000333964"
FT   DNA_BIND        22..92
FT                   /note="OB"
FT   REGION          111..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   203 AA;  21717 MW;  B89A3485277BF7B6 CRC64;
     MTTETFVKDV KPGLKNLSVL FIVLETGRVT KTKDGHEVRT CKVADKTGSI NISVWDDLGN
     FIQPGDIIRL TKGYASLFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYIAQQS
     QNKQAQAESG TGTNSHNSSS PAPPASDLEN GNGSNSSGPP THQSTAPTHS TSGRITRSQP
     NHSIPGAPNS VSNGKEPRRT GKR