SOSB2_BOVIN
ID SOSB2_BOVIN Reviewed; 206 AA.
AC A5D7P8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=SOSS complex subunit B2;
DE AltName: Full=Nucleic acid-binding protein 1;
DE AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2A;
DE AltName: Full=Sensor of single-strand DNA complex subunit B2;
DE AltName: Full=Sensor of ssDNA subunit B2;
DE Short=SOSS-B2;
DE AltName: Full=Single-stranded DNA-binding protein 2;
GN Name=NABP1; Synonyms=OBFC2A, SSB2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC DNA that binds to single-stranded DNA, in particular to
CC polypyrimidines. The SOSS complex associates with DNA lesions and
CC influences diverse endpoints in the cellular DNA damage response
CC including cell-cycle checkpoint activation, recombinational repair and
CC maintenance of genomic stability. Required for efficient homologous
CC recombination-dependent repair of double-strand breaks (DSBs) and ATM-
CC dependent signaling pathways (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SOSS complex, composed of SOSS-B (SOSS-
CC B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS
CC complexes containing SOSS-B1/NABP2 are more abundant than complexes
CC containing SOSS-B2/NABP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC foci following DNA damage. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B2 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC140638; AAI40639.1; -; mRNA.
DR RefSeq; NP_001091593.1; NM_001098124.1.
DR RefSeq; XP_015313759.1; XM_015458273.1.
DR RefSeq; XP_015313764.1; XM_015458278.1.
DR RefSeq; XP_015313765.1; XM_015458279.1.
DR AlphaFoldDB; A5D7P8; -.
DR SMR; A5D7P8; -.
DR STRING; 9913.ENSBTAP00000024821; -.
DR PaxDb; A5D7P8; -.
DR PRIDE; A5D7P8; -.
DR Ensembl; ENSBTAT00000024821; ENSBTAP00000024821; ENSBTAG00000018653.
DR GeneID; 613474; -.
DR KEGG; bta:613474; -.
DR CTD; 64859; -.
DR VEuPathDB; HostDB:ENSBTAG00000018653; -.
DR VGNC; VGNC:31859; NABP1.
DR eggNOG; KOG3416; Eukaryota.
DR GeneTree; ENSGT00940000155812; -.
DR HOGENOM; CLU_102724_0_1_1; -.
DR InParanoid; A5D7P8; -.
DR OMA; HTVMTTI; -.
DR OrthoDB; 1512483at2759; -.
DR TreeFam; TF313902; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000018653; Expressed in granulosa cell and 106 other tissues.
DR ExpressionAtlas; A5D7P8; baseline.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0070876; C:SOSS complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0010212; P:response to ionizing radiation; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..206
FT /note="SOSS complex subunit B2"
FT /id="PRO_0000333953"
FT DNA_BIND 26..89
FT /note="OB"
FT REGION 114..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 22449 MW; E030CBFAB2C061A8 CRC64;
MNGVRDPPLF IKDIKPGLKN LNVVFIVLEI GRVTKTKDGH EVRSCKVADK TGSITISVWD
EIGGLIQPGD IIRLTRGYAS MWKGCLTLYT GRGGELQKIG EFCMVYSELP NFSEPNPDYR
GQQNKGAHNE QKNNSMNNSN NVGTGTFGPM GNGVQTGAEA RGCQFSYAGR SNGRGPINPQ
LPGTANNQTV MTTISNGRDP RRAFKR
