ID   SOSB2_DANRE             Reviewed;         211 AA.
AC   Q5PRC7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=SOSS complex subunit B2;
DE   AltName: Full=Nucleic acid-binding protein 1;
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2A;
DE   AltName: Full=Sensor of single-strand DNA complex subunit B2;
DE   AltName: Full=Sensor of ssDNA subunit B2;
DE            Short=SOSS-B2;
DE   AltName: Full=Single-stranded DNA-binding protein 2;
GN   Name=nabp1; Synonyms=obfc2a, ssb2; ORFNames=zgc:101644;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC       DNA that binds to single-stranded DNA. The SOSS complex associates with
CC       DNA lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of soss-b (soss-
CC       b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip. SOSS
CC       complexes containing soss-b1/nabp2 are more abundant than complexes
CC       containing soss-b2/nabp1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC086713; AAH86713.1; -; mRNA.
DR   RefSeq; NP_001008643.1; NM_001008643.1.
DR   AlphaFoldDB; Q5PRC7; -.
DR   SMR; Q5PRC7; -.
DR   STRING; 7955.ENSDARP00000005126; -.
DR   PaxDb; Q5PRC7; -.
DR   GeneID; 494100; -.
DR   KEGG; dre:494100; -.
DR   CTD; 494100; -.
DR   ZFIN; ZDB-GENE-041212-71; nabp1a.
DR   eggNOG; KOG3416; Eukaryota.
DR   InParanoid; Q5PRC7; -.
DR   OrthoDB; 1512483at2759; -.
DR   PhylomeDB; Q5PRC7; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q5PRC7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..211
FT                   /note="SOSS complex subunit B2"
FT                   /id="PRO_0000333957"
FT   DNA_BIND        27..97
FT                   /note="OB"
FT   REGION          125..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..190
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  22438 MW;  F27FC501188E17D3 CRC64;
     MSNISNEAVI LIKDVKPGSK NLNIVFIVLE IGRVTKTKDG HEVRSCRVAD KSGSIAISVW
     DELGSLIQPG DIIRLTRGYA SIWKGCLTLY TGRGGDLQKI GEFCMVYSEV PNFSEPNPEL
     LAQANQQNKT SKEQRGNSPP NQNAGNGTVP VFSNNNAAPV PRDPNFGASG RPNGRAPGNG
     PPPVTAGGTP APPKPTVSIS NGRDPRRASK R