ID   SOSB2_RAT               Reviewed;         198 AA.
AC   Q5FVP2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=SOSS complex subunit B2;
DE   AltName: Full=Nucleic acid-binding protein 1;
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2A;
DE   AltName: Full=Sensor of single-strand DNA complex subunit B2;
DE   AltName: Full=Sensor of ssDNA subunit B2;
DE            Short=SOSS-B2;
DE   AltName: Full=Single-stranded DNA-binding protein 2;
GN   Name=Nabp1; Synonyms=Obfc2a, Ssb2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC       DNA that binds to single-stranded DNA, in particular to
CC       polypyrimidines. The SOSS complex associates with DNA lesions and
CC       influences diverse endpoints in the cellular DNA damage response
CC       including cell-cycle checkpoint activation, recombinational repair and
CC       maintenance of genomic stability. Required for efficient homologous
CC       recombination-dependent repair of double-strand breaks (DSBs) and ATM-
CC       dependent signaling pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of SOSS-B (SOSS-
CC       B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS
CC       complexes containing SOSS-B1/NABP2 are more abundant than complexes
CC       containing SOSS-B2/NABP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC089852; AAH89852.1; -; mRNA.
DR   RefSeq; NP_001014238.1; NM_001014216.1.
DR   AlphaFoldDB; Q5FVP2; -.
DR   SMR; Q5FVP2; -.
DR   STRING; 10116.ENSRNOP00000021403; -.
DR   PaxDb; Q5FVP2; -.
DR   Ensembl; ENSRNOT00000021403; ENSRNOP00000021403; ENSRNOG00000015416.
DR   GeneID; 363227; -.
DR   KEGG; rno:363227; -.
DR   UCSC; RGD:1306658; rat.
DR   CTD; 64859; -.
DR   RGD; 1306658; Nabp1.
DR   eggNOG; KOG3416; Eukaryota.
DR   GeneTree; ENSGT00940000155812; -.
DR   HOGENOM; CLU_102724_0_1_1; -.
DR   InParanoid; Q5FVP2; -.
DR   OMA; HTVMTTI; -.
DR   OrthoDB; 1512483at2759; -.
DR   PhylomeDB; Q5FVP2; -.
DR   TreeFam; TF313902; -.
DR   Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q5FVP2; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000015416; Expressed in adult mammalian kidney and 18 other tissues.
DR   Genevisible; Q5FVP2; RN.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISO:RGD.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISO:RGD.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..198
FT                   /note="SOSS complex subunit B2"
FT                   /id="PRO_0000333956"
FT   DNA_BIND        26..89
FT                   /note="OB"
FT   REGION          142..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  21855 MW;  C9BD8D02A3252B2F CRC64;
     MHGVNDPPLF IKDIKAGLKN LNVVFIVLEI GRVTKTKDGH EVRSCKVADR TGSITISVWD
     EIGGLIQTGD IIRLTRGYAS MWKGCLTLYT GRGGELQKIG EFCMVYSEVP NFSEPNPDYR
     GQQNRVVQNE QKDKMNTSIF GTVGNGVQTG PESRGYPLQY GRSNGPGPIS PQLPGEPSNQ
     TVRTTISNAR DPRRAFKR