SOSD1_CHICK
ID SOSD1_CHICK Reviewed; 206 AA.
AC Q6VYA3;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Sclerostin domain-containing protein 1;
DE AltName: Full=Wnt-signaling modulator;
DE Flags: Precursor;
GN Name=SOSTDC1; Synonyms=WISE;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH LRP6, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=12900447; DOI=10.1242/dev.00674;
RA Itasaki N., Jones C.M., Mercurio S., Rowe A., Domingos P.M., Smith J.C.,
RA Krumlauf R.;
RT "Wise, a context-dependent activator and inhibitor of Wnt signalling.";
RL Development 130:4295-4305(2003).
CC -!- FUNCTION: Can activate or inhibit Wnt signaling in a context-dependent
CC manner. Activates the canonical Wnt pathway whereby acts through
CC Disheveled proteins and beta-catenin. Antagonises Wnt signaling through
CC the canonical pathways presumably by blocking accessibility of certain
CC WNTs to their receptors. Induces posterior neural markers via
CC components of the canonical Wnt pathway. {ECO:0000269|PubMed:12900447}.
CC -!- SUBUNIT: Interacts with LRP6. {ECO:0000269|PubMed:12900447}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Expression was first detected broadly at stage 9,
CC and then localized in the posterior surface ectoderm overlying the
CC presomitic mesoderm by stage 10-11 embryo.
CC {ECO:0000269|PubMed:12900447}.
CC -!- SIMILARITY: Belongs to the sclerostin family. {ECO:0000305}.
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DR EMBL; AY319926; AAQ57626.1; -; mRNA.
DR RefSeq; NP_989704.1; NM_204373.1.
DR RefSeq; XP_015136747.1; XM_015281261.1.
DR AlphaFoldDB; Q6VYA3; -.
DR SMR; Q6VYA3; -.
DR ELM; Q6VYA3; -.
DR STRING; 9031.ENSGALP00000041999; -.
DR PaxDb; Q6VYA3; -.
DR Ensembl; ENSGALT00000080778; ENSGALP00000044773; ENSGALG00000036836.
DR GeneID; 378800; -.
DR KEGG; gga:378800; -.
DR CTD; 25928; -.
DR VEuPathDB; HostDB:geneid_378800; -.
DR eggNOG; ENOG502QV5G; Eukaryota.
DR GeneTree; ENSGT00390000014900; -.
DR HOGENOM; CLU_087969_0_0_1; -.
DR InParanoid; Q6VYA3; -.
DR OMA; KFWARRS; -.
DR OrthoDB; 1511387at2759; -.
DR PhylomeDB; Q6VYA3; -.
DR TreeFam; TF353019; -.
DR PRO; PR:Q6VYA3; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000036836; Expressed in ovary and 5 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR008835; Sclerostin/SOSTDC1.
DR PANTHER; PTHR14903; PTHR14903; 1.
DR Pfam; PF05463; Sclerostin; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW Wnt signaling pathway.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..206
FT /note="Sclerostin domain-containing protein 1"
FT /id="PRO_0000033184"
FT DOMAIN 75..170
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 40..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..206
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 75..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 89..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 100..163
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 104..165
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 206 AA; 23144 MW; 75F438854599CEAD CRC64;
MLLSAIHFYG LLLACTFTRS YSAFKNDATE ILYSHVVKPA PASPSSNSTL NQARNGGRHY
AGTGSDRNNR VQVGCRELRS TKYISDGQCT SINPLKELVC AGECLPLPLL PNWIGGGYGT
KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG SIRTYKITVV TACKCKRYTR QHNESSHNFE
GTSQAKPVQH HKERKRASKS SKHSTS
