ID   SOSSC_BOVIN             Reviewed;         104 AA.
AC   Q2NKT2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=SOSS complex subunit C;
DE   AltName: Full=INTS3- and NABP-interacting protein;
DE   AltName: Full=Sensor of single-strand DNA complex subunit C;
DE   AltName: Full=Sensor of ssDNA subunit C;
DE            Short=SOSS-C;
DE   AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE            Short=SSB-interacting protein 1;
GN   Name=INIP; Synonyms=SSBIP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC       lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) and ATM-dependent signaling pathways (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of SOSS-B (SOSS-
CC       B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS
CC       complexes containing SOSS-B1/NABP2 are more abundant than complexes
CC       containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is
CC       direct (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
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DR   EMBL; BC111656; AAI11657.1; -; mRNA.
DR   RefSeq; NP_001071532.1; NM_001078064.2.
DR   AlphaFoldDB; Q2NKT2; -.
DR   SMR; Q2NKT2; -.
DR   STRING; 9913.ENSBTAP00000025666; -.
DR   PaxDb; Q2NKT2; -.
DR   PRIDE; Q2NKT2; -.
DR   Ensembl; ENSBTAT00000025666; ENSBTAP00000025666; ENSBTAG00000019275.
DR   GeneID; 616784; -.
DR   KEGG; bta:616784; -.
DR   CTD; 58493; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019275; -.
DR   VGNC; VGNC:30204; INIP.
DR   eggNOG; ENOG502S23S; Eukaryota.
DR   GeneTree; ENSGT00390000006366; -.
DR   HOGENOM; CLU_145773_1_0_1; -.
DR   InParanoid; Q2NKT2; -.
DR   OMA; DCKVLTN; -.
DR   OrthoDB; 1596201at2759; -.
DR   TreeFam; TF328613; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000019275; Expressed in oocyte and 112 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; IEA:Ensembl.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR031821; SOSSC.
DR   PANTHER; PTHR31526; PTHR31526; 1.
DR   Pfam; PF15925; SOSSC; 1.
PE   3: Inferred from homology;
KW   Acetylation; DNA damage; DNA repair; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRY2"
FT   CHAIN           2..104
FT                   /note="SOSS complex subunit C"
FT                   /id="PRO_0000279418"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRY2"
SQ   SEQUENCE   104 AA;  11419 MW;  2B506B7BDF176ED1 CRC64;
     MAANPSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPA LNKDFRDHAE
     QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE